Frequency of the MDR1 mutant allele associated with multidrug sensitivity in dogs from Brazil.

Autor:	Monobe MM; Department of Veterinary Clinics, School of Veterinary Medicine and Animal Science., Junior JPA; Department of Microbiology and Immunology, Biosciences Institute, Sao Paulo State University (UNESP), Botucatu, Brazil., Lunsford KV; Department of Clinical Sciences and Animal Health Center., Silva RC; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi, MS, USA, bulla@cvm.msstate.edu., Bulla C; Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi, MS, USA, bulla@cvm.msstate.edu.
Jazyk:	angličtina
Zdroj:	Veterinary medicine (Auckland, N.Z.) [Vet Med (Auckl)] 2015 Apr 13; Vol. 6, pp. 111-117. Date of Electronic Publication: 2015 Apr 13 (Print Publication: 2015).
DOI:	10.2147/VMRR.S72373
Abstrakt:	To date, a 4-bp deletion in the MDR1 gene has been detected in more than ten dog breeds, as well as in mixed breed dogs, in several countries, however information regarding this mutation in dogs from Brazil is lacking. For this reason, 103 Collies, 77 Border Collies, 76 Shetland Sheepdogs, 20 Old English Sheepdogs, 55 German Shepherds, 16 Australian Shepherds, and 53 Whippets from Brazil were screened for the presence of the mutation. The heterozygous mutated genotype, MDR1 (+/-), frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 50.5% (95% CI =41.1%-59.9%), 31.3% (95% CI =8.6%-53.2%), and 15.8% (95% CI =7.7%-23.9%), respectively. Homozygous mutated genotype, MDR1 (-/-), was detected only in Collies 35.9%. The MDR1 allele mutant frequency found for Collies, Australian Shepherd, and Shetland Sheepdog was 61.2% (95% CI =54.8%-67.5%), 15.6% (95% CI =3.1%-28.2%), and 7.9% (95% CI =3.7%-12.1%), respectively. Additionally, even free of the mutant allele, the maximum mutant prevalence (MMP) in that population, with 95% CI, was 3.8%, 5.2%, 5.4%, and 13.8% for Border Collies, German Shepherds, Whippets, and Old English Sheepdogs, respectively. In this way, this information is important, not only for MDR1 genotype-based breeding programs and international exchange of breeding animals of predisposed breeds, but also for modification of drug therapy for breeds at risk. Competing Interests: Disclosure The authors report no conflicts of interest in this work.
Databáze:	MEDLINE
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