Multiorgan dysfunction syndrome in feline sepsis: prevalence and prognostic implication.

Autor:	Troìa R; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Mascalzoni G; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Calipa S; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Magagnoli I; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Dondi F; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy., Giunti M; Department of Veterinary Medical Science, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
Jazyk:	angličtina
Zdroj:	Journal of feline medicine and surgery [J Feline Med Surg] 2019 Jun; Vol. 21 (6), pp. 559-565. Date of Electronic Publication: 2018 Aug 13.
DOI:	10.1177/1098612X18792106
Abstrakt:	Objectives: The current study was designed to evaluate the prevalence and prognostic significance of multiorgan dysfunction syndrome (MODS) in cats with sepsis. Methods: Cats hospitalised in the intensive care unit of a veterinary university hospital with a diagnosis of sepsis were prospectively enrolled and divided according to disease severity and outcome (survivors; non-survivors). The feline acute patient physiological and laboratory evaluation (APPLE) scores were calculated upon admission, as previously described. Specific criteria to identify selected organ dysfunction (hepatic, renal, respiratory, cardiocirculatory, haemostatic) were adapted from the available human and veterinary literature, and evaluated at baseline and at the end of hospital stay. MODS was defined as the presence of at least two dysfunctional organs simultaneously. Non-parametric statistics were used for comparisons. Univariate and multivariate regression analyses to evaluate significant risk factors for death were carried out. Correlations between variables were assessed by the Spearman's rank correlation coefficient. Significance was set at P <0.05. Results: A total of 43 cats with heterogeneous sources of sepsis were included. MODS was identified in 25/43 cats upon admission and in 32/43 cats at the end of hospital stay. Regression analyses showed a significantly elevated odds ratio for mortality for the presence of MODS, renal and cardiovascular dysfunction upon admission, as well as for the number of dysfunctional organs. The latter was the only variable retained by the model from the multivariate binary logistic regression analysis. Significant correlations were documented between the number of dysfunctional organs and the APPLE scores. Conclusions and Relevance: MODS is a frequent complication of feline sepsis, and is associated with worse outcomes. In particular, renal and cardiovascular dysfunction significantly increase the odds for death. Hence, systematic screening for organ dysfunction is advocated in cats with sepsis.
Databáze:	MEDLINE
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