A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D 2 O solvation.

Autor: Cho A; Department of Biochemistry & Structural Biology, Weill Cornell Graduate School, New York City, NY 10065, United States; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York City, NY 10065, United States. Electronic address: anc2075@med.cornell.edu., Eskandari R; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, United States. Electronic address: eskandar@mskcc.org., Miloushev VZ; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, United States. Electronic address: miloushv@mskcc.org., Keshari KR; Department of Biochemistry & Structural Biology, Weill Cornell Graduate School, New York City, NY 10065, United States; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, United States; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, United States. Electronic address: rahimikk@mskcc.org.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance (San Diego, Calif. : 1997) [J Magn Reson] 2018 Oct; Vol. 295, pp. 57-62. Date of Electronic Publication: 2018 Aug 02.
DOI: 10.1016/j.jmr.2018.08.001
Abstrakt: Although dissolution dynamic nuclear polarization is a robust technique to significantly increase magnetic resonance signal, the short T 1 relaxation time of most 13 C-nuclei limits the timescale of hyperpolarized experiments. To address this issue, we have characterized a non-synthetic approach to extend the hyperpolarized lifetime of 13 C-nuclei in close proximity to solvent-exchangeable protons. Protons exhibit stronger dipolar relaxation than deuterium, so dissolving these compounds in D 2 O to exchange labile protons with solvating deuterons results in longer-lived hyperpolarization of the 13 C-nucleus 2-bonds away. 13 C T 1 and T 2 times were longer in D 2 O versus H 2 O for all molecules in this study. This phenomenon can be utilized to improve hyperpolarized signal-to-noise ratio as a function of longer T 1 , and enhanced spectral and imaging resolution via longer T 2 .
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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