| Autor: |
Betul Ergul A; 1 Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey., Turanoglu C; 1 Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey., Karakukcu C; 2 Department of Biochemistry, Kayseri Training and Research Hospital, Kayseri, Turkey., Guler Kazanci E; 3 Department of Pediartic Hematology, Bursa Dortcelik Children Hospital, Bursa, Turkey., Altuner Torun Y; 4 Department of Pediatric Hematology, Kayseri Training and Research Hospital, Kayseri, Turkey. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition [Int J Vitam Nutr Res] 2017 Sep; Vol. 87 (5-6), pp. 247-252. Date of Electronic Publication: 2018 Aug 10. |
| DOI: |
10.1024/0300-9831/a000444 |
| Abstrakt: |
Additional nutritional deficiencies may accompany zinc deficiency. We determined the vitamin B 12 levels in patients with zinc (Zn) deficiency. This retrospective study enrolled 256 patients age 6 months to 16 years (176 females and 80 males) in whom Zn levels in hair samples were measured concurrently with serum vitamin B 12 and ferritin levels. For all patients, we retrospectively assessed the hair Zn levels, serum ferritin and vitamin B 12 levels, red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution levels. Data were analyzed to determine whether there was a significant difference between any of these parameters and the presence of vitamin B 12 deficiency between patients with and without Zn deficiency. In all 118 patients had Zn levels < 100 μg/g and 138 patients had levels > 100 μg/g. No significant differences were observed in ferritin levels, red blood cell parameters, or presence of iron deficiency or anemia between the two groups ( p > 0.05). The median vitamin B 12 level was 323 (range 238-440) pg/mL in the Zn-deficient group and 276 (range 208-382) pg/mL in those with normal Zn levels. Vitamin B 12 levels were significantly higher in the Zn-deficient group (p = 0.02). A significant negative correlation was detected between vitamin B 12 levels and Zn levels (r = -0.17, p = 0.004). Vitamin B 12 levels are higher in patients with Zn deficiency; thus, Zn may have a negative effect on vitamin B 12 levels. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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