The hypothalamic-pituitary-testicular axis and the testicular function are modulated after silver nanoparticle exposure.

Autor:	Cavallin MD; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br., Wilk R; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br., Oliveira IM; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br., Cardoso NCS; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br., Khalil NM; Laboratory of Nanotechnology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil., Oliveira CA; Laboratory of Hormonal Dosages , Department of Animal Reproduction , Faculty of Veterinary Medicine , University of Sao Paulo , Av. Prof. Dr. Orlando Marques de Paiva , 87 , 05508-270 , Sao Paulo , Brazil., Romano MA; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br., Romano RM; Laboratory of Reproductive Toxicology , Department of Pharmacy , State University of Centro-Oeste , Rua Simeao Camargo Varela de Sa , 03 , 85040-080 , Parana , Brazil . Email: romano@unicentro.br.
Jazyk:	angličtina
Zdroj:	Toxicology research [Toxicol Res (Camb)] 2017 Nov 23; Vol. 7 (1), pp. 102-116. Date of Electronic Publication: 2017 Nov 23 (Print Publication: 2018).
DOI:	10.1039/c7tx00236j
Abstrakt:	Silver nanoparticles (AgNPs) are widely used in industrial and medical applications and humans may be exposed through different routes, increasing the risk of toxicity. We investigated the transcript expression of genes involved in the regulation of the hypothalamic-pituitary-testicular (HPT) axis and the parameters associated with sperm functionality after prepubertal exposure. AgNPs modulated the transcript expression of genes involved in the control of the HPT axis and spermatogenesis in the groups treated with lower doses, while the functional parameters related to sperm and puberty were affected in the groups administered higher doses. These results suggest that the HPT axis is disrupted by AgNPs during the prepubertal and pubertal periods, which are highly susceptible windows for the endocrine-disrupting chemical activity.
Databáze:	MEDLINE
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