A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity.

Autor: Krasilnikova AA; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.; Scientific Institute of Clinical and Experimental Lymphology , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation., Solovieva AO; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.; Scientific Institute of Clinical and Experimental Lymphology , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation., Ivanov AA; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.; Nikolaev Institute of Inorganic Chemistry SB RAS , 3 Acad. Lavrentiev Ave. , 630090 Novosibirsk , Russian Federation., Brylev KA; Nikolaev Institute of Inorganic Chemistry SB RAS , 3 Acad. Lavrentiev Ave. , 630090 Novosibirsk , Russian Federation.; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation., Pozmogova TN; Scientific Institute of Clinical and Experimental Lymphology , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation.; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation., Gulyaeva MA; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation., Kurskaya OG; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53., Alekseev AY; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53., Shestopalov AM; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53., Shestopalova LV; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation., Poveshchenko AF; Scientific Institute of Clinical and Experimental Lymphology , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation., Efremova OA; Department of Chemistry , University of Hull , Cottingham Road , Hull , HU6 7RX , UK . Email: o.efremova@hull.ac.uk ; Tel: +44 (0)1482 465417., Mironov YV; Nikolaev Institute of Inorganic Chemistry SB RAS , 3 Acad. Lavrentiev Ave. , 630090 Novosibirsk , Russian Federation.; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation., Shestopalov MA; Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.; Scientific Institute of Clinical and Experimental Lymphology , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation.; Nikolaev Institute of Inorganic Chemistry SB RAS , 3 Acad. Lavrentiev Ave. , 630090 Novosibirsk , Russian Federation.; Novosibirsk State University , 2 Pirogova Str. , 630090 Novosibirsk , Russian Federation.
Jazyk: angličtina
Zdroj: Toxicology research [Toxicol Res (Camb)] 2017 May 17; Vol. 6 (4), pp. 554-560. Date of Electronic Publication: 2017 May 17 (Print Publication: 2017).
DOI: 10.1039/c7tx00083a
Abstrakt: The octahedral rhenium cluster compound Na 2 H 8 [{Re 6 Se 8 }(P(C 2 H 4 CONH 2 )(C 2 H 4 COO) 2 ) 6 ] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C 2 H 4 CN) 3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na 2 H 8 [{Re 6 Se 8 }(P(C 2 H 4 CONH 2 )(C 2 H 4 COO) 2 ) 6 ] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na 2 H 14 [{Re 6 Q 8 }(P(C 2 H 4 COO) 3 ) 6 ] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na 2 H 8 [{Re 6 Se 8 }(P(C 2 H 4 CONH 2 )(C 2 H 4 COO) 2 ) 6 ] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C 2 H 4 COOH) 3 . Such behavior can be explained by the higher osmolality of Na 2 H 14 [{Re 6 Q 8 }(P(C 2 H 4 COO) 3 ) 6 ] versus Na 2 H 8 [{Re 6 Se 8 }(P(C 2 H 4 CONH 2 )(C 2 H 4 COO) 2 ) 6 ].
Databáze: MEDLINE
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