Safety of a 2-Day Antibiotic Regimen After Delayed Chest Closure Post Pediatric Cardiac Surgery.

Autor:	Philip J; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Kegg C; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Lopez-Colon D; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Kelly BJ; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Lawrence RM; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Robinson MA; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Samraj RS; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA., Bleiweis MS; Congenital Heart Center, UF Health Shands Children's Hospital, University of Florida, Gainesville, FL, USA.
Jazyk:	angličtina
Zdroj:	Journal of intensive care medicine [J Intensive Care Med] 2020 Aug; Vol. 35 (8), pp. 805-809. Date of Electronic Publication: 2018 Aug 08.
DOI:	10.1177/0885066618792849
Abstrakt:	Background: There is no consensus for the length of prophylactic antibiotics after delayed chest closure (DCC) postcardiac surgery in pediatrics. In September 2014, our institution's pediatric cardiac intensive care unit changed the policy on length of prophylactic antibiotics after DCC from 5 days (control) to 2 days (study group). The objective of the study was to determine whether a 2-day course of antibiotics is as effective as a 5-day course in preventing blood stream and sternal wound infections in pediatric DCC. Methods: Retrospective and prospective study. Primary end points included incidence of sternal wound infections and positive sternal imaging for infection. Surrogate markers of infection were collected at 4 time points. Results: During the study period, 139 patients had DCC postcardiac surgery of which 110 patients were included for analysis, 54 patients in the control and 56 in the study group. There was no difference in total number of positive wound cultures/chest computed tomography (CT) findings (4/54 [7.5%] control vs 5/56 [8.9%] study group, P = .3), positive blood cultures ( P = .586), median postsurgical length of stay ( P = .4), or readmissions within 30 days postsurgery ( P = .6). All secondary end points were similar in both groups except peak heart rate between weeks 2 and 4 ( P = .041). Conclusion: Two days of prophylactic antibiotics is not inferior to 5 days of prophylactic antibiotics after DCC following pediatric cardiac surgery.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu