Dietary stearic acid regulates mitochondria in vivo in humans.

Autor: Senyilmaz-Tiebe D; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Heidelberg University, 69120, Heidelberg, Germany., Pfaff DH; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, 69120, Heidelberg, Germany., Virtue S; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, CB2 0QQ, UK., Schwarz KV; Center for Child and Adolescent Medicine, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany., Fleming T; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, 69120, Heidelberg, Germany.; German Center for Diabetes Research (DZD), 69120, Heidelberg, Germany.; Joint Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) and Heidelberg Center for Molecular Biology (ZMBH), University Hospital Heidelberg, 69120, Heidelberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Institute for Diabetes and Cancer, IDC Helmholtz Center Munich, 69120, Heidelberg, Germany., Altamura S; Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69120, Heidelberg, Germany.; Molecular Medicine Partnership Unit, 69120, Heidelberg, Germany., Muckenthaler MU; Department of Pediatric Hematology, Oncology and Immunology, University of Heidelberg, 69120, Heidelberg, Germany.; Molecular Medicine Partnership Unit, 69120, Heidelberg, Germany., Okun JG; Center for Child and Adolescent Medicine, Division of Neuropediatrics and Metabolic Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 669, 69120, Heidelberg, Germany., Vidal-Puig A; University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, CB2 0QQ, UK.; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK., Nawroth P; Department of Internal Medicine I and Clinical Chemistry, Heidelberg University Hospital, 69120, Heidelberg, Germany.; German Center for Diabetes Research (DZD), 69120, Heidelberg, Germany.; Joint Division Molecular Metabolic Control, German Cancer Research Center (DKFZ) and Heidelberg Center for Molecular Biology (ZMBH), University Hospital Heidelberg, 69120, Heidelberg, Germany.; Joint Heidelberg-IDC Translational Diabetes Program, Institute for Diabetes and Cancer, IDC Helmholtz Center Munich, 69120, Heidelberg, Germany., Teleman AA; German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. a.teleman@dkfz.de.; Heidelberg University, 69120, Heidelberg, Germany. a.teleman@dkfz.de.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2018 Aug 07; Vol. 9 (1), pp. 3129. Date of Electronic Publication: 2018 Aug 07.
DOI: 10.1038/s41467-018-05614-6
Abstrakt: Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and thereby mitochondrial morphology and function in cell culture. Whether this pathway is poised to sense changes in dietary intake of C18:0 in humans is not known. We show here that C18:0 ingestion rapidly and robustly causes mitochondrial fusion in people within 3 h after ingestion. C18:0 intake also causes a drop in circulating long-chain acylcarnitines, suggesting increased fatty acid beta-oxidation in vivo. This work thereby identifies C18:0 as a dietary metabolite that is sensed by our bodies to control our mitochondria. This could explain part of the epidemiological differences between C16:0 and C18:0, whereby C16:0 increases cardiovascular and cancer risk whereas C18:0 decreases both.
Databáze: MEDLINE