[Risk of Stroke After Exacerbation of Ischemic Heart Disease: Data of 3‑Years Follow-up].

Autor:	Brazhnik VA; City clinical hospital №51., Minushkina LO; Federal State Budgetary Institution 'Educational and Scientific Medical Center' at the Department of Presidential Affairs., Evdokimova MA; City clinical hospital №51., Galyavich AS; Federal State Budget Educational Institution of Higher Education, 'Kazan State Medical University' of the Ministry of Health of the Russian Federation., Tereshchenko SN; Federal State Budgetary Institution, 'Russian Cardiology Science and Production Center' of the Ministry of Health of the Russian Federation., Koziolova NA; Federal State Budgetary Educational Institution of Higher Education, 'Academician E. A. Vagner Perm State Medical Academy' of the Ministry of Health of the Russian Federation., Glezer MG; Federal State Budgetary Educational Institution of Higher Education 'I. M. Sechenov First Moscow State Medical University' of the Ministry of Health of the Russian Federation., Yagoda AV; State Budgetary Educational Institution of Higher Professional Education, 'Stavropol State Medical University' of the Ministry of Healthcare., Khorolets EV; Federal State Budgetary Educational Institution of Higher Education 'Rostov State Medical University' of the Ministry of Health of the Russian Federation., Dankovtseva EN; City clinical hospital №51., Boeva OI; State Budgetary Educational Institution of Higher Professional Education, 'Stavropol State Medical University' of the Ministry of Healthcare., Konstantinov VO; State Budgetary Educational Institution of Higher Professional Education, 'I. I. Mechnikov North-West State Medical University' of the RF Ministry of Health Care., Zateishchikov DA; City clinical hospital №51.
Jazyk:	ruština
Zdroj:	Kardiologiia [Kardiologiia] 2018 Jul; Vol. 58 (7), pp. 14-22.
Abstrakt:	Purpose: to analyze possible associations of clinical and genetic factors with development of ischemic stroke after exacerbation of ischemic heart disease (IHD). Materials and Methods: The Russian multicenter study aimed at assessment of risk of unfavorable outcomes after exacerbation of IHD "Exacerbation of IHD: logical probabilistic ways to course prognostication for optimization of treatment" (meaning of Cyrillic acronym - oracle) was conducted in 16 centers of 7 cities in Russia. We included into the study 1 208 patients with unstable angina and ST-elevation or non-ST-elevation myocardial infarction (MI). Data on outcomes were known for 1 193 patients, 15 patients were lost for follow-up. Results: Mean duration of follow-up was 644±14.45 (4-1 995) days. Shortest, longest, and mean time before development of stroke was 22, 1433 and 389±56.6 days after inclusion. Patients with strokes were older, more often had history of IHD prior to index hospitalization, arterial blood pressure level compatible with stage 3 arterial hypertension, less often were smokers, and more often had MI recurrences or repetitive episodes of severe ischemia during the index hospitalization. Patients also more often had documented atrial fibrillation during hospitalization, and lower level of glomerular filtration rate. Of studied genetic markers carriage of A allele of polymorphic marker G (-1082) A of interleukin-10 gene was significantly associated with risk of stroke development. Using linear regression analysis, we constructed a model of estimation of the stroke development risk. Comparison of diagnostic value of different scales for stroke risk assessment showed that area under the curve was 0.656, 0.686, and 0.756 for the GRACE, CHA2DS2‑VASc, and ORACLE scores, respectively.
Databáze:	MEDLINE
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