Exploring the margins of SERS in practical domain: An emerging diagnostic modality for modern biomedical applications.

Autor: Joseph MM; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Narayanan N; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Nair JB; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Karunakaran V; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Ramya AN; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Sujai PT; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Saranya G; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Arya JS; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Vijayan VM; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India., Maiti KK; Chemical Sciences and Technology Division, CSIR- National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Pappanamcode, Thiruvananthapuram, Kerala 695019, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NIIST, Pappanamcode, Thiruvananthapuram, Kerala 695019, India. Electronic address: kkmaiti@niist.res.in.
Jazyk: angličtina
Zdroj: Biomaterials [Biomaterials] 2018 Oct; Vol. 181, pp. 140-181. Date of Electronic Publication: 2018 Jul 26.
DOI: 10.1016/j.biomaterials.2018.07.045
Abstrakt: Excellent multiplexing capability, molecular specificity, high sensitivity and the potential of resolving complex molecular level biological compositions augmented the diagnostic modality of surface-enhanced Raman scattering (SERS) in biology and medicine. While maintaining all the merits of classical Raman spectroscopy, SERS provides a more sensitive and selective detection and quantification platform. Non-invasive, chemically specific and spatially resolved analysis facilitates the exploration of SERS-based nano probes in diagnostic and theranostic applications with improved clinical outcomes compared to the currently available so called state-of-art technologies. Adequate knowledge on the mechanism and properties of SERS based nano probes are inevitable in utilizing the full potential of this modality for biomedical applications. The safety and efficiency of metal nanoparticles and Raman reporters have to be critically evaluated for the successful translation of SERS in to clinics. In this context, the present review attempts to give a comprehensive overview about the selected medical, biomedical and allied applications of SERS while highlighting recent and relevant outcomes ranging from simple detection platforms to complicated clinical applications.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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