Molecular epidemiology and risk factors for colistin- or tigecycline-resistant carbapenemase-producing Klebsiella pneumoniae bloodstream infection in critically ill patients during a 7-year period.

Autor: Papadimitriou-Olivgeris M; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Bartzavali C; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Spyropoulou A; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Lambropoulou A; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Sioulas N; Anesthesiology and Critical Care Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Vamvakopoulou S; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Karpetas G; Anesthesiology and Critical Care Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Spiliopoulou I; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Vrettos T; Anesthesiology and Critical Care Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Anastassiou ED; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Fligou F; Anesthesiology and Critical Care Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Christofidou M; Department of Microbiology, School of Medicine, University of Patras, 26504, Rion-Patras, Greece., Marangos M; Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Patras, 26504, Rion-Patras, Greece. Electronic address: mmarangos@yahoo.com.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2018 Nov; Vol. 92 (3), pp. 235-240. Date of Electronic Publication: 2018 Jun 07.
DOI: 10.1016/j.diagmicrobio.2018.06.001
Abstrakt: A matched 1:2 case-control study was conducted among critically ill patients in order to identify the risk factors of colistin or tigecycline-resistant carbapenemase-producing Klebsiella pneumoniae (ColR-Kp, TigR-Kp) bacteraemia. MIC to colistin and tigecycline were determined by Etest. From 224 bacteraemic patients, 46.4% and 29.5% were resistant to colistin and tigecycline, respectively. PCR revealed that 199 isolates carried the bla KPC gene. PCR revealed that no isolate carried the mcr-1 gene. Risk factors for ColR-Kp bacteraemia as compared to patients with bacteraemia by a colistin-susceptible isolate or patients without carbapenemase-producing K. pneumoniae bacteraemia were colistin or tigecycline administration and tracheostomy, while TigR-Kp bacteraemia as compared to either patients with bacteraemia by tigecycline-susceptible isolate or patients without carbapenemase-producing K. pneumoniae bacteraemia were colistin or tigecycline administration, number of comorbidities and prior bacteraemia by a Gram-negative pathogen. Administration of colistin and tigecycline predisposed to development of bacteraemia by either ColR-Kp or TigR-Kp.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: