| Autor: |
Blasco V; Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain., Murga J, Falomir E, Carda M, Royo S, Cuñat AC, Sanz-Cervera JF, Marco JA |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2018 Aug 15; Vol. 16 (32), pp. 5859-5870. |
| DOI: |
10.1039/c8ob01148f |
| Abstrakt: |
Several tricyclic compounds inspired by the structure of combretastatin A-4 and bearing group 14 elements have been synthesized by homocoupling lithiated aryl fragments followed by ring-closing metathesis. These tricyclic compounds and their diolefin precursors were evaluated for their antiproliferative action on the tumor cell lines HT-29, MCF-7, HeLa and A-549 and on the non-tumor cell line HEK-293. In addition, their effects on the cell cycle were also measured. The tricyclic compounds show antiproliferative activity similar to that of combretastatin A-4, even though they are not so active in arresting the cell cycle. However, some diolefin precursors are able to cause accumulation of cells in the G2/M phase in a higher percentage than combretastatin A-4 itself. Inhibition of endothelial tube formation and VEGFR-2 phosphorylation of some selected compounds is comparable to that of combretastatin A-4, particularly those of tin-containing compounds 23c and 26c, whose actions exceed those of sorafenib, a clinically used VEGFR-2 inhibitor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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