Combination of virtual point detector concept and fluence compensation in acoustic resolution photoacoustic microscopy.
| Autor: | Perekatova VV; Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia., Kirillin MY; Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia., Turchin IV; Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia., Subochev PV; Russian Academy of Sciences, Institute of Applied Physics, Nizhny Novgorod, Russia. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Journal of biomedical optics [J Biomed Opt] 2018 Jul; Vol. 23 (9), pp. 1-11. |
| DOI: | 10.1117/1.JBO.23.9.091414 |
| Abstrakt: | We propose a hybrid approach to image enhancement in acoustic resolution photoacoustic microscopy. The developed technique is based on compensation for nonuniform spatial sensitivity of the optoacoustic (OA) system in both optical and acoustic domains. Spatial distribution of optical fluence is derived from full three-dimensional Monte Carlo simulations accounting for conical geometry of tissue laser illumination at the wavelength of 532 nm. Approximate nonuniform spatial response of acoustic detector with numerical aperture of 0.6 is derived from the two-dimensional k-Wave modeling. Application of the developed technique allows to improve the spatial resolution and to balance in-depth signal-level distribution in OA images of phantom and in-vivo objects. ((2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|