Extreme long-term voice outcomes after concurrent chemoradiotherapy for advanced non-laryngeal head and neck cancer: Eight-year post-treatment analysis.
Autor: | Davies-Husband C; Queen Victoria Head and Neck Unit, Brighton and Sussex University Hospital, Brighton, UK., Murphy J; Freeman Hospital, Newcastle upon Tyne, UK., Kelly C; Freeman Hospital, Newcastle upon Tyne, UK., Drinnan M; University of Newcastle upon Tyne, Newcastle upon Tyne, UK., Paleri V; Royal Marsden Hospital, London, UK. |
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Jazyk: | angličtina |
Zdroj: | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery [Clin Otolaryngol] 2018 Dec; Vol. 43 (6), pp. 1494-1499. Date of Electronic Publication: 2018 Sep 06. |
DOI: | 10.1111/coa.13204 |
Abstrakt: | Background: The long-term effect of concurrent chemoradiation on voice outcomes in the context of non-laryngeal head and neck cancer is not established. Methods: A prospective, observational study to evaluate the voice quality in disease-free patients receiving concurrent chemoradiation for advanced non-laryngeal squamous cell carcinoma of the upper aerodigestive tract. Voice assessment occurred at four distinct time-points: pretreatment, 3, 12 and 92.6 months (mean) post-treatment in 34, 21 and nine patients, respectively. The authors used a combination of subjective (VoiSS questionnaire), expert rater-assessed (GRBAS scale) and acoustic analysis of the fundamental frequency to assess voice outcomes. Ethical approval was obtained from the United Kingdom National Research Ethics Service. Results: Both the VoiSS impairment and GRBAS domains continued to deteriorate over time from pre-treatment to 92.6 months post-treatment (P = 0.03). There was a strong correlation between increase in total VoiSS and GRBAS scores (r = 0.93). Acoustic analysis demonstrated no statistically significant variation in fundamental frequency. Conclusion: Radiation therapy for advanced non-laryngeal head and neck has a significant, deleterious effect on voice, which is apparent up to eight years post-treatment. (© 2018 John Wiley & Sons Ltd.) |
Databáze: | MEDLINE |
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