Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome.

Autor:	Surikow SY; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Nguyen TH; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Stafford I; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chapman M; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chacko S; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Singh K; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Licari G; Basil Hetzel Institute, Adelaide, South Australia, Australia., Raman B; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia., Kelly DJ; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Zhang Y; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Waddingham MT; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia., Ngo DT; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Bate AP; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Chua SJ; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia., Frenneaux MP; University of East Anglia, Norfolk, United Kingdom., Horowitz JD; The Queen Elizabeth Hospital, Department of Cardiology, University of Adelaide, South Australia, Australia.; Basil Hetzel Institute, Adelaide, South Australia, Australia.
Jazyk:	angličtina
Zdroj:	JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Apr 18; Vol. 3 (2), pp. 213-226. Date of Electronic Publication: 2018 Apr 18 (Print Publication: 2018).
DOI:	10.1016/j.jacbts.2017.10.002
Abstrakt:	Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress. Therefore, we first showed in a female rat model that isoproterenol induces TS-like echocardiographic changes, evidence of nitrosative stress, and consequent activation of the energy-depleting enzyme poly(ADP-ribose) polymerase-1. We subsequently showed that pre-treatment with an inhibitor of poly(ADP-ribose) polymerase-1 ameliorated contractile abnormalities. These findings thus add to previous reports of aberrant β-adrenoceptor signaling (coupled with nitric oxide synthase activation) to elucidate mechanisms of impaired cardiac function in TS and point to potential methods of treatment.
Databáze:	MEDLINE
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