Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction.

Autor: de Carvalho LP; Federal University of Sao Paulo State, Sao Paulo, Brazil.; National University Heart Center, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Albert Einstein Hospital, São Paulo, Brazil., Tan SH; National University Heart Center, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ow GS; Bioinformatics Institute, ASTAR, Singapore., Tang Z; Bioinformatics Institute, ASTAR, Singapore.; Institute of Molecular and Cell Biology, ASTAR, Singapore., Ching J; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore., Kovalik JP; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore., Poh SC; National University Heart Center, Singapore, Singapore., Chin CT; Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore.; National Heart Centre Singapore, Singapore., Richards AM; National University Heart Center, Singapore, Singapore.; Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand., Martinez EC; Miller School of Medicine, University of Miami, Miami, Florida., Troughton RW; Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand., Fong AY; Clinical Research Centre, Sarawak General Hospital, Kuching, Malaysia.; Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia., Yan BP; Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Seneviratna A; National University Heart Center, Singapore, Singapore., Sorokin V; National University Heart Center, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Summers SA; University of Utah, Salt Lake City, Utah., Kuznetsov VA; Bioinformatics Institute, ASTAR, Singapore.; Nanyang Institute of Technology in Health & Medicine, Nanyang Technological University, Singapore., Chan MY; National University Heart Center, Singapore, Singapore.; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jazyk: angličtina
Zdroj: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 May 30; Vol. 3 (2), pp. 163-175. Date of Electronic Publication: 2018 May 30 (Print Publication: 2018).
DOI: 10.1016/j.jacbts.2017.12.005
Abstrakt: We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.
Databáze: MEDLINE