| Autor: |
Hermenau R; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany., Ishida K; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany., Gama S; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Jena, Germany., Hoffmann B; Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany., Pfeifer-Leeg M; Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany., Plass W; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Jena, Germany., Mohr JF; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Jena, Germany., Wichard T; Institute for Inorganic and Analytical Chemistry, Friedrich Schiller University, Jena, Germany., Saluz HP; Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.; Friedrich Schiller University, Faculty of Biology and Pharmacy, Jena, Germany., Hertweck C; Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany. christian.hertweck@hki-jena.de.; Friedrich Schiller University, Faculty of Biology and Pharmacy, Jena, Germany. christian.hertweck@hki-jena.de. |
| Abstrakt: |
Genome mining and chemical analyses revealed that rhizosphere bacteria (Paraburkholderia graminis) produce a new type of siderophore, gramibactin, a lipodepsipeptide that efficiently binds iron with a logβ value of 27.6. Complexation-induced proton NMR chemical shifts show that the unusual N-nitrosohydroxylamine (diazeniumdiolate) moieties participate in metal binding. Gramibactin biosynthesis genes are conserved in numerous plant-associated bacteria associated with rice, wheat, and maize, which may utilize iron from the complex. |
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