Risk of acute myeloid leukemia and myelodysplastic syndrome after autotransplants for lymphomas and plasma cell myeloma.

Autor: Radivoyevitch T; Departments of Quantitative Health Sciences and Translational Hematology & Oncology Research, Cleveland Clinic Foundation, Cleveland, OH, United States., Dean RM; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Shaw BE; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: beshaw@mcw.edu., Brazauskas R; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States; Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States., Tecca HR; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States., Molenaar RJ; Departments of Quantitative Health Sciences and Translational Hematology & Oncology Research, Cleveland Clinic Foundation, Cleveland, OH, United States; Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands., Battiwalla M; Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD, United States., Savani BN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Flowers MED; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Cooke KR; Pediatric Blood and Marrow Transplantation Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, United States., Hamilton BK; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Kalaycio M; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Maciejewski JP; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Ahmed I; Department of Hematology Oncology and Bone Marrow Transplantation, The Children's Mercy Hospitals and Clinics, Kansas City, MO, United States., Akpek G; Stem Cell Transplantation and Cell Therapy, Rush University Medical Center, Chicago, IL, United States., Bajel A; Royal Melbourne Hospital City Campus, Melbourne, Australia., Buchbinder D; Division of Pediatrics Hematology, Children's Hospital of Orange County, Orange, CA, United States., Cahn JY; Department of Hematology, CHU Grenoble Alpes, Grenoble, France., D'Souza A; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States., Daly A; Tom Baker Cancer Center, Calgary, AB, Canada., DeFilipp Z; Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, United States., Ganguly S; Blood and Marrow Transplantation, University of Kansas Medical Center, Kansas City, KS, United States., Hamadani M; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States., Hayashi RJ; Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, United States., Hematti P; Department of Medicine, University of Wisconsin Hospital and Clinics, Madison, WI, United States., Inamoto Y; Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan., Khera N; Department of Hematology/Oncology, Mayo Clinic, Phoenix, AZ, United States., Kindwall-Keller T; Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, VA, United States., Landau H; Bone Marrow Transplant Service, Division of Hematology, Memorial Sloan Kettering Cancer Center, New York, NY, United States., Lazarus H; Seidman Cancer Center, Case Western Reserve University, Cleveland, OH, United States., Majhail NS; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Marks DI; Adult Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom., Olsson RF; Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden., Seo S; Department of Hematology & Oncology, National Cancer Research Center East, Chiba, Japan., Steinberg A; Department of Hematology-Oncology, Mount Sinai Hospital, New York, NY, United States., William BM; Ohio State Medical Center, Columbus, OH, United States., Wirk B; Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, WA, United States., Yared JA; Department of Medicine, University of Maryland, Baltimore, MD, United States., Aljurf M; Department of Oncology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia., Abidi MH; Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States., Allewelt H; Duke University Medical Center, Durham, NC, United States., Beitinjaneh A; University of Miami, Miami, FL, United States., Cook R; Oregon Health and Science University, Portland, OR, United States., Cornell RF; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Fay JW; Baylor University Medical Center, Dallas, TX, United States., Hale G; Department of Hematology/Oncology, Johns Hopkins All Children's Hospital, St. Petersburg, FL, United States., Chakrabarty JH; Department of Hematology/Oncology, University of Oklahoma, Oklahoma City, OK, United States., Jodele S; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States., Kasow KA; University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Mahindra A; Scripps Blood & Marrow Transplant Program, La Jolla, CA, United States., Malone AK; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY; United States., Popat U; MD Anderson Cancer Center, Houston, TX, United States., Rizzo JD; CIBMTR (Center for International Blood and Marrow Transplant Research), Medical College of Wisconsin, Milwaukee, WI, United States., Schouten HC; Department of Hematology, Academische Ziekenhuis, Maastricht, Netherlands., Warwick AB; Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States., Wood WA; University of North Carolina at Chapel Hill, Chapel Hill, NC, United States., Sekeres MA; Blood & Marrow Transplant Program, Cleveland Clinic, Cleveland, Ohio, United States., Litzow MR; Dept. Of Medicine, Mayo Clinic, Rochester, MN, United States., Gale RP; Department of Medicine, Imperial College London, London, United Kingdom., Hashmi SK; Department of Oncology, King Faisal Specialist Hospital, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: Leukemia research [Leuk Res] 2018 Nov; Vol. 74, pp. 130-136. Date of Electronic Publication: 2018 Jul 19.
DOI: 10.1016/j.leukres.2018.07.016
Abstrakt: Background: Exposures to DNA-damaging drugs and ionizing radiations increase risks of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS).
Methods: 9028 recipients of hematopoietic cell autotransplants (1995-2010) for Hodgkin lymphoma (HL; n = 916), non-Hodgkin lymphoma (NHL; n = 3546) and plasma cell myeloma (PCM; n = 4566), reported to the CIBMTR, were analyzed for risk of subsequent AML or MDS.
Results: 335 MDS/AML cases were diagnosed posttransplant (3.7%). Variables associated with an increased risk for AML or MDS in multivariate analyses were: (1) conditioning with total body radiation versus chemotherapy alone for HL (HR = 4.0; 95% confidence interval [1.4, 11.6]) and NHL (HR = 2.5 [1.1, 2.5]); (2) ≥3 versus 1 line of chemotherapy for NHL (HR = 1.9 [1.3, 2.8]); and (3) subjects with NHL transplanted in 2005-2010 versus 1995-1999 (HR = 2.1 [1.5, 3.1]). Using Surveillance, Epidemiology and End Results (SEER) data, we found risks for AML/MDS in HL, NHL and PCM to be 5-10 times the background rate. In contrast, relative risks were 10-50 for AML and approximately 100 for MDS in the autotransplant cohort.
Conclusions: There are substantial risks of AML and MDS after autotransplants for HL, NHL and PCM.
(Copyright © 2018. Published by Elsevier Ltd.)
Databáze: MEDLINE
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