19 F PARASHIFT Probes for Magnetic Resonance Detection of H 2 O 2 and Peroxidase Activity.

Autor: Yu M; Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States., Bouley BS; Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States., Xie D; Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States., Enriquez JS; Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States., Que EL; Department of Chemistry , University of Texas at Austin , Austin , Texas 78712-1224 , United States.
Jazyk: angličtina
Zdroj: Journal of the American Chemical Society [J Am Chem Soc] 2018 Aug 22; Vol. 140 (33), pp. 10546-10552. Date of Electronic Publication: 2018 Aug 13.
DOI: 10.1021/jacs.8b05685
Abstrakt: Elevated levels of reactive oxygen species and peroxidase expression are often associated with inflammation and inflammatory diseases. We developed two novel Co(II) complexes that can be used to detect oxidative activity associated with inflammation using 19 F magnetic resonance imaging (MRI). These agents display a large change in 19 F chemical shift upon oxidation from Co(II) to Co(III), facilitating selective visualization of both species using chemical shift selective pulse sequences. This large chemical shift change is attributed to a large magnetic anisotropy in the high spin Co(II) complexes. Importantly, the differing reactivity of the two agents allows for detection of either H 2 O 2 production and/or the activity of peroxidase enzymes, providing two useful platforms for 19 F MR hot spot imaging of oxidative events associated with biological inflammation.
Databáze: MEDLINE
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