Deregulation of the G1/S-phase transition is the proximal cause of mortality in old yeast mother cells.

Autor:	Neurohr GE; David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Terry RL; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Sandikci A; David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA., Zou K; Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA., Li H; Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94158, USA., Amon A; David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Jazyk:	angličtina
Zdroj:	Genes & development [Genes Dev] 2018 Aug 01; Vol. 32 (15-16), pp. 1075-1084. Date of Electronic Publication: 2018 Jul 24.
DOI:	10.1101/gad.312140.118
Abstrakt:	Budding yeast cells produce a finite number of daughter cells before they die. Why old yeast cells stop dividing and die is unclear. We found that age-induced accumulation of the G1/S-phase inhibitor Whi5 and defects in G1/S cyclin transcription cause cell cycle delays and genomic instability that result in cell death. We further identified extrachromosomal rDNA (ribosomal DNA) circles (ERCs) to cause the G1/S cyclin expression defect in old cells. Spontaneous segregation of Whi5 and ERCs into daughter cells rejuvenates old mothers, but daughters that inherit these aging factors die rapidly. Our results identify deregulation of the G1/S-phase transition as the proximal cause of age-induced proliferation decline and cell death in budding yeast. (© 2018 Neurohr et al.; Published by Cold Spring Harbor Laboratory Press.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu