Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies.

Autor: Yu JJ; a Department of Ophthalmology , University of California , Irvine , CA , USA., Lee DH; a Department of Ophthalmology , University of California , Irvine , CA , USA., Gallagher SP; a Department of Ophthalmology , University of California , Irvine , CA , USA., Kenney MC; a Department of Ophthalmology , University of California , Irvine , CA , USA., Boisvert CJ; a Department of Ophthalmology , University of California , Irvine , CA , USA.
Jazyk: angličtina
Zdroj: Current eye research [Curr Eye Res] 2018 Oct; Vol. 43 (10), pp. 1199-1204. Date of Electronic Publication: 2018 Aug 07.
DOI: 10.1080/02713683.2018.1504086
Abstrakt: There is growing evidence for the role of mitochondrial dysfunction in the toxic optic neuropathies. Due to the structural similarities between antibiotic targets and mitochondrial machinery, several antibiotics known to cause optic neuropathy have deleterious effects on mitochondrial function. We review the literature on the prevalence, clinical manifestations, and management of antibiotic induced toxic optic neuropathies. The effect of these antibiotics on mitochondrial function in regard to the optic nerve is discussed.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje