Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study.

Autor:	Akinyemi RO; 1 Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; 2 Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.; 3 Federal Medical Centre, Abeokuta, Nigeria., Sarfo FS; 4 Kwame Nkrumah University of Science & Technology, Kumasi, Ghana., Akinyemi J; 5 Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria., Singh A; 4 Kwame Nkrumah University of Science & Technology, Kumasi, Ghana., Onoja Akpa M; 5 Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria., Akpalu A; 6 Department of Medicine, University of Ghana, Accra, Ghana., Owolabi L; 7 Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria., Adeoye AM; 1 Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Obiako R; 9 Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria., Wahab K; 10 Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Sanya E; 10 Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Komolafe M; 11 Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria., Ogbole G; 12 Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Fawale M; 11 Department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria., Adebayo P; 13 Department of Medicine, Ladoke Akintola University Teaching Hospital, Ogbomoso, Nigeria., Osaigbovo G; 14 Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria., Sunmonu T; 15 Department of Medicine, Federal Medical Centre, Owo, Nigeria., Olowoyo P; 16 Department of Medicine, Federal University Teaching Hospital, Ido-Ekiti, Nigeria., Chukwuonye I; 17 Department of Medicine, Federal Medical Centre, Umuahia, Nigeria., Obiabo Y; 18 Department of Medicine, Delta State University Teaching Hospital, Igharra, Nigeria., Adeniji O; 3 Federal Medical Centre, Abeokuta, Nigeria., Fakunle G; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Melikam E; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Saulson R; 19 Department of Neurosciences, Medical University of South Carolina, Charleston, USA., Yaria J; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Uwanruochi K; 17 Department of Medicine, Federal Medical Centre, Umuahia, Nigeria., Ibinaiye P; 9 Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria., Amusa GA; 14 Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria., Yahaya IS; 7 Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria., Dambatta AH; 7 Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria., Faniyan M; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Olowoniyi P; 17 Department of Medicine, Federal Medical Centre, Umuahia, Nigeria., Bock-Oruma A; 18 Department of Medicine, Delta State University Teaching Hospital, Igharra, Nigeria., Joseph OC; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Oguntade A; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Kolo P; 10 Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Laryea R; 6 Department of Medicine, University of Ghana, Accra, Ghana., Lakoh S; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Uvere E; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Farombi T; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Akpalu J; 6 Department of Medicine, University of Ghana, Accra, Ghana., Oyinloye O; 10 Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria., Appiah L; 4 Kwame Nkrumah University of Science & Technology, Kumasi, Ghana., Calys-Tagoe B; 6 Department of Medicine, University of Ghana, Accra, Ghana., Shidali V; 9 Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria., Tabari NA; 7 Aminu Kano Teaching Hospital, Bayero University, Kano, Nigeria., Adebayo O; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Efidi R; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Adeleye O; 3 Federal Medical Centre, Abeokuta, Nigeria., Owusu D; 4 Kwame Nkrumah University of Science & Technology, Kumasi, Ghana., Ogunjimi L; 20 Department of Medicine, University College Hospital, Ibadan, Nigeria., Aridegbe O; 3 Federal Medical Centre, Abeokuta, Nigeria., Imoh CL; 14 Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria., Sanni T; 16 Department of Medicine, Federal University Teaching Hospital, Ido-Ekiti, Nigeria., Gebreziabher M; 19 Department of Neurosciences, Medical University of South Carolina, Charleston, USA., Hemant T; 21 Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA., Arulogun O; 22 Department of Health Promotion and Education, University of Ibadan, Ibadan, Nigeria., Ogunniyi A; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Jenkins C; 19 Department of Neurosciences, Medical University of South Carolina, Charleston, USA., Owolabi M; 1 Centre for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.; 8 Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ovbiagele B; 19 Department of Neurosciences, Medical University of South Carolina, Charleston, USA.
Jazyk:	angličtina
Zdroj:	International journal of stroke : official journal of the International Stroke Society [Int J Stroke] 2019 Jan; Vol. 14 (1), pp. 69-79. Date of Electronic Publication: 2018 Jul 24.
DOI:	10.1177/1747493018790059
Abstrakt:	Background: It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective: To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods: A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results: Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25-1.81) and a family history of stroke (OR 1.20, 1.03-1.39) while Islamic religion (OR=0.82, CI: 0.72-0.94), being currently unmarried (OR = 0.81, CI: 0.70-0.92), and alcohol use (OR = 0.78, CI: 0.67-0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03-1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65-0.96). Conclusion: To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu