Effects of injectable trace minerals administered concurrently with a modified live virus vaccine on long-term protection against bovine viral diarrhea virus acute infection in dairy calves.

Autor: Bittar JHJ; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States., Hoyos-Jaramillo A; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States., Hurley DJ; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States., Woolums AR; Department of Pathobiology and Population Medicine, College of Veterinary Medicine Mississippi State University, Mississippi State, MS 39762, United States., Havenga LJ; Multimin®USA, Inc. Fort Collins, CO 80528, United States., Lourenço JM; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602-2771, United States., Barnett G; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States., Gomes V; College of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP 05508-270, Brazil., Saliki JT; Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States., Harmon DD; Department of Crop and Soil Science, University of Georgia, Athens, GA 30602-2771, United States., Palomares RA; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-2771, United States. Electronic address: palomnr@uga.edu.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2018 Aug; Vol. 119, pp. 250-258. Date of Electronic Publication: 2018 Jul 21.
DOI: 10.1016/j.rvsc.2018.07.003
Abstrakt: The objective was to evaluate the effects of injectable trace minerals (ITM) concurrent with modified-live virus (MLV) vaccination on protection from bovine viral diarrhea virus (BVDV) infection in dairy calves. In a previous study (Palomares et al., 2016), thirty dairy calves received two doses of a MLV vaccine subcutaneously (SC), concurrently with ITM (n = 15) or saline (n = 15), SC. Five months later, 20 of these calves received ITM (G1, n = 10) or saline (G2, n = 10) according to their previous groups and were challenged intranasally with BVDV2. Five unvaccinated calves were also challenged with BVDV2 (G3). Blood samples were collected on days 0 (BVDV challenge), 3, 5, 6, 7, 8, 9, 11, 14, 18, 21, 32 and 61 for leukocyte count, virus isolation and BVDV serum neutralizing antibodies (SNA). Mild-moderate clinical signs were observed in G3 after BVDV challenge. Group 1 showed lower sum health score and nasal score on d5 and fecal score on d8 compared to G2. Rectal temperature and leukocyte counts were not different between G1 and G2. In contrast, G3 calves had significant leukopenia and lymphopenia from d3 to d7 (P < .05) and higher rectal temperatures on d6 to d8, compared to values on d0 (P < .05). All unvaccinated calves became viremic, while viremia was not detected in G1 or G2. Average daily gain was not different between vaccinated groups, however, only G1 calves had significantly greater (P = .04) ADG compared to non-vaccinated calves during the first 14 days post challenge. Vaccinated calves treated or not with ITM were protected from BVDV2 infection five months post-vaccination.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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