Protein phosphatases in chromatin structure and function.

Autor: Gil RS; Colleges of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London, London UB8 3PH, UK., Vagnarelli P; Colleges of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London, London UB8 3PH, UK. Electronic address: Paola.Vagnarelli@Brunel.ac.uk.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2019 Jan; Vol. 1866 (1), pp. 90-101. Date of Electronic Publication: 2018 Jul 20.
DOI: 10.1016/j.bbamcr.2018.07.016
Abstrakt: Chromatin structure and dynamics are highly controlled and regulated processes that play an essential role in many aspects of cell biology. The chromatin transition stages and the factors that control this process are regulated by post-translation modifications, including phosphorylation. While the role of protein kinases in chromatin dynamics has been quite well studied, the nature and regulation of the counteracting phosphatases represent an emerging field but are still at their infancy. In this review we summarize the current literature on phosphatases involved in the regulation of chromatin structure and dynamics, with emphases on the major knowledge gaps that should require attention and more investigation.
(Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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