ENIGMA MILITARY BRAIN INJURY: A COORDINATED META-ANALYSIS OF DIFFUSION MRI FROM MULTIPLE COHORTS.

Autor: Dennis EL; Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA., Wilde EA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.; Department of Neurology, University of Utah, Salt Lake City, UT, USA.; Department of Radiology, Baylor College of Medicine, Houston, TX, USA., Newsome MR; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA., Scheibel RS; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA., Troyanskaya M; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA., Velez C; University of Missouri-St. Louis, St. Louis, MO, USA., Wade BSC; University of Missouri-St. Louis, St. Louis, MO, USA.; Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA., Drennon AM; Defense and Veterans Brain Injury Center, San Antonio, TX, USA., York GE; Alaska Radiology Associates, Anchorage, AK, USA., Bigler ED; Department of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA., Abildskov TJ; Department of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA., Taylor BA; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.; Department of Radiology, Baylor College of Medicine, Houston, TX, USA., Jaramillo CA; Polytrauma Rehabilitation Center, South Texas Veterans Health Care System, San Antonio, TX., Eapen B; Polytrauma Rehabilitation Center, South Texas Veterans Health Care System, San Antonio, TX., Belanger H; James A. Haley Veterans Hospital, Tampa, FL, USA.; University of South Florida, Tampa, FL, USA., Gupta V; Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA., Morey R; Psychiatry, Duke University, Durham, NC., Haswell C; Psychiatry, Duke University, Durham, NC., Levin HS; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.; Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA., Hinds SR 2nd; Department of Defense/United States Army Medical Research and Materiel Command., Walker WC; Defense and Veterans Brain Injury Center, San Antonio, TX, USA.; Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond VA.; Hunter Holmes McGuire VAMC, Richmond VA., Thompson PM; Imaging Genetics Center, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.; Departments of Neurology, Pediatrics, Psychiatry, Radiology, Engineering, and Ophthalmology, USC, Los Angeles, CA., Tate DF; University of Missouri-St. Louis, St. Louis, MO, USA.
Jazyk: angličtina
Zdroj: Proceedings. IEEE International Symposium on Biomedical Imaging [Proc IEEE Int Symp Biomed Imaging] 2018 Apr; Vol. 2018, pp. 1386-1389. Date of Electronic Publication: 2018 May 24.
DOI: 10.1109/ISBI.2018.8363830
Abstrakt: Traumatic brain injury (TBI) is a significant cause of morbidity in military Veterans and Service Members. While most individuals recover fully from mild injuries within weeks, some continue to experience symptoms including headaches, disrupted sleep, and other cognitive, behavioral or physical symptoms. Diffusion magnetic resonance imaging (dMRI) shows promise in identifying areas of structural disruption and predicting outcomes. Although some studies suggest widespread structural disruption after brain injury, dMRI studies of military brain injury have yielded mixed results so far, perhaps due to the subtlety of mild injury, individual differences in injury location, severity and mechanism, and comorbidity with other disorders such as post-traumatic stress disorder (PTSD), depression, and substance abuse. We present preliminary dMRI results from the ENIGMA (Enhancing Neuroimaging Genetics through Meta-Analysis) military brain injury working group. We found higher fractional anisotropy (FA) in participants with a history of TBI. Understanding the injury and recovery process, along with factors that influence these, will lead to improved diagnosis and treatment.
Databáze: MEDLINE