Outcome of Nonsurgical Management of Extra-Abdominal, Trunk, and Abdominal Wall Desmoid-Type Fibromatosis: A Population-Based Study in the Netherlands.

Autor: van Broekhoven DLM; Department of Surgery, Erasmus MC Cancer Institute, P.O. Box 5201, 3008 AE Rotterdam, Netherlands., Verschoor AJ; Department of Medical Oncology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, Netherlands., van Dalen T; Department of Surgery, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, Netherlands.; Department of Surgery, Diakonessenhuis, Postbus 80250, 3508 TG Utrecht, Netherlands., Grünhagen DJ; Department of Surgery, Erasmus MC Cancer Institute, P.O. Box 5201, 3008 AE Rotterdam, Netherlands., den Bakker MA; Department of Pathology, Erasmus MC Cancer Institute, P.O. Box 5201, 3008 AE Rotterdam, Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, Netherlands., Bovee JVMG; Department of Pathology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, Netherlands., Haas RLM; Department of Radiotherapy, Netherlands Cancer Institute-Antoni van Leeuwenhoek, P.O. Box 90203, 1006 BE Amsterdam, Netherlands., Bonenkamp HJ; Department of Surgery, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands., van Coevorden F; Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek, P.O. Box 90203, 1006 BE Amsterdam, Netherlands., Ten Oever D; Department of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, P.O. Box 90203, 1006 BE Amsterdam, Netherlands., van der Graaf WTA; Deparment of Medical Oncology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands.; Clinical and Translational Sarcoma Research, The Institute of Cancer Research, The Royal Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, London, Surrey SM2 5NG, UK., Flucke UE; Department of Pathology, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, Netherlands., Pras E; Department of Radiotherapy, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, Netherlands., Reyners AKL; Department of Medical Oncology, University Medical Center Groningen, University of Groningen, P.O. Box 30001, 9700 RB Groningen, Netherlands., Westermann AM; Department of Medical Oncology, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, Netherlands., Oldenburger F; Department of Radiotherapy, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, Netherlands., Verhoef C; Department of Surgery, Erasmus MC Cancer Institute, P.O. Box 5201, 3008 AE Rotterdam, Netherlands., Steeghs N; Department of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, P.O. Box 90203, 1006 BE Amsterdam, Netherlands.
Jazyk: angličtina
Zdroj: Sarcoma [Sarcoma] 2018 Jun 21; Vol. 2018, pp. 5982575. Date of Electronic Publication: 2018 Jun 21 (Print Publication: 2018).
DOI: 10.1155/2018/5982575
Abstrakt: Introduction: Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome of first-line nonsurgical management strategies.
Patients and Methods: From the Dutch Pathology Registry (PALGA), patients with extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 and 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start of treatment/surveillance until change of treatment or last follow-up was analyzed.
Results: Ninety-one of the 1141 identified patients had first-line nonsurgical management. The percentage of patients treated nonsurgically increased from 0.6% in 1993-1998 to 12.8% in 2009-2013. Thirty-seven patients had surveillance (41%), 35 radiotherapy (38%), and 19 systemic treatment (21%). BR for surveillance was complete response (CR) in 2/37, partial response (PR) in 4/37, stable disease (SD) in 21/37, progressive disease (PD) in 5/37, and unknown in 5/37 patients. BR for radiotherapy was CR in 4/35, PR in 11/35, SD in 16/35, and unknown in 4/35. BR for systemic treatment was CR in 1/19, PR in 1/19, SD in 10/19, PD in 2/19, and unknown in 5/19. Totally, 91% of patients did not progress.
Discussion: Given the low percentage (9%) of PD of nonsurgical management, these data can be used in shared decision making with the patient regarding optimal treatment.
Databáze: MEDLINE
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