Comparison of hepatic arterial infusion chemotherapy between 5-fluorouracil-based continuous infusion chemotherapy and low-dose cisplatin monotherapy for advanced hepatocellular carcinoma.

Autor: Kawaoka T; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Aikata H; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Kobayashi T; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Uchikawa S; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Ohya K; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Kodama K; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Nishida Y; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Daijo K; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Osawa M; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Teraoka Y; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Inagaki Y; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Honda F; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Hatooka M; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Morio K; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Morio R; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Fujino H; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Nakahara T; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Murakami E; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Tsuge M; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Hiramatsu A; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Imamura M; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Kawakami Y; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan., Baba Y; Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan., Awai K; Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan., Chayama K; Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.; Liver Research Project Center, Hiroshima University, Hiroshima, Japan.
Jazyk: angličtina
Zdroj: Hepatology research : the official journal of the Japan Society of Hepatology [Hepatol Res] 2018 Dec; Vol. 48 (13), pp. 1118-1130. Date of Electronic Publication: 2018 Aug 23.
DOI: 10.1111/hepr.13232
Abstrakt: Aim: The aim of this study is to compare the efficacy and safety of hepatic arterial infusion chemotherapy (HAIC) between 5-fluorouracil (5-FU)-based continuous infusion chemotherapy and low-dose cisplatin (CDDP) monotherapy in patients with advanced hepatocellular carcinoma (HCC).
Methods: Patients were grouped according to HAIC regimen (5-FU group, n = 317/CDDP group, n = 66). A two-to-one match was created using propensity score analysis (5-FU group, n = 102/CDDP group, n = 51). After matching, response rate (RR) and adverse events as primary end-points, and survival and progression-free survival as secondary end-points, were analyzed.
Results: In the analysis of primary end-points, the RR in the 5-FU group was significantly higher than in the CDDP group (32.4% vs. 15.7%, P = 0.033). In patients with a Child-Pugh (CP) score of 5-7, the RR in the 5-FU group was significantly higher than that in the CDDP group (36.1% vs. 15.4%, P = 0.020). In those with a CP score of 8-9, there was no significant difference in RR between the two groups (15.8% vs. 16.6%, P = 1.000). The reservoir system-related complications were 9.8% in the 5-FU group, and there was no significant difference in the incidence of grade 3/4 adverse events between the two matched groups (P > 0.05). In terms of secondary end-points, the median survival time was 9.1 and 8.7 months for the 5-FU and CDDP groups, respectively (P = 0.4917). Progression-free survival was 3.9 months for the 5-FU group and 4.9 months for the CDDP group (P = 0.4).
Conclusions: 5-Fluorouracil-based continuous infusion chemotherapy could be suitable for advanced HCC patients with a CP score of 5-7 considering the treatment response.
(© 2018 The Japan Society of Hepatology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje