| Autor: |
Kumi Smith M; University of North Carolina Chapel Hill, Chapel Hill, NC, USA. kumi.smith@unc.edu., Jewell BL; University of California Berkeley, Berkeley, CA, USA., Hallett TB; Imperial College of London, London, UK., Cohen MS; University of North Carolina Chapel Hill, Chapel Hill, NC, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Advances in experimental medicine and biology [Adv Exp Med Biol] 2018; Vol. 1075, pp. 125-162. |
| DOI: |
10.1007/978-981-13-0484-2_6 |
| Abstrakt: |
The scientific breakthrough proving that antiretroviral therapy (ART) can halt heterosexual HIV transmission came in the form of a landmark clinical trial conducted among serodiscordant couples. Study findings immediately informed global recommendations for the use of treatment as prevention in serodiscordant couples. The extent to which these findings are generalizable to other key populations or to groups exposed to HIV through nonsexual transmission routes (i.e., anal intercourse or unsafe injection of drugs) has since driven a large body of research. This review explores the history of HIV research in serodiscordant couples, the implications for management of couples, subsequent research on treatment as prevention in other key populations, and challenges in community implementation of these strategies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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