| Autor: |
Fouad HM; Pediatric Department, Faculty of Medicine, Helwan University, Cairo, Egypt. hananminaped@gmail.com., Reyad EM; Departments of Clinical and Chemical Pathology, National Hepatology and Tropical Medicine Research Institute 'NHTMRI', Cairo, Egypt., El-Din AG; Departments of Clinical Chemistry, National Hepatology and Tropical Medicine Research Institute 'NHTMRI', Cairo, Egypt. |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2018 Oct; Vol. 37 (10), pp. 1941-1947. Date of Electronic Publication: 2018 Jul 20. |
| DOI: |
10.1007/s10096-018-3329-0 |
| Abstrakt: |
Acute hepatic illness is an important health issue in children. Our work aimed to determine the prevalence of viral hepatitis in symptomatic children. It is a prospective cohort study of 268 children presented with acute hepatitis. Complete blood count, liver panel, and anti-hepatitis A virus (HAV) IgM were done initially. Cases negative for HAV were tested for anti-hepatitis E (HEV) IgM, anti-Epstein-Barr virus viral capsid antigen (EBV VCA) IgM, anti-cytomegalovirus virus IgM, hepatitis B surface antigen, anti-hepatitis B core IgM antibody, and anti-HCV antibody. Anti-HCV was repeated after 12 weeks to exclude seroconversion. In cases with negative viral serology, ceruloplasmin, total immunoglobulin G, antinuclear antibody, and abdominal ultrasound were done. Follow-up visits were bimonthly till recovery, then after 6 months. The mean age ± SD was 7.1 ± 3.7 years (1.5-18), and 56% were males. Acute HAV infection was diagnosed in 260 (97%) of cases and acute EBV infection in one case (0.4%). HAV/HEV coinfection was excluded in 70 HAV-positive cases. Six (2.2%) children remain undiagnosed and one child lost follow-up. About 80% of HAV-cases had normal laboratory results within 45 days. Unusual presentation of HAV infection was noticed in six children: four (1.5%) were relapsing, one had a cholestatic course, and one case had severe hemolytic anemia. Acute HAV infection was the chief etiology of acute hepatitis in our Egyptian children. The majority of the presentations were mild and children recover within a few weeks. An unusual pattern of HAV in children can be observed in endemic areas. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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