| Autor: |
Homm RE, Foldesy RG, Hahn DW |
| Jazyk: |
angličtina |
| Zdroj: |
Contraception [Contraception] 1985 Sep; Vol. 32 (3), pp. 267-74. |
| DOI: |
10.1016/0010-7824(85)90050-2 |
| Abstrakt: |
A sulfonated polystyrene polymer, ORF 13904, was discovered in our laboratory to be a highly effective vaginal contraceptive in the rabbit model and to possess a unique mode of action. It was found to be non-spermicidal even at high concentrations, yet it greatly impeded sperm penetration of cervical mucus in vitro. When a gel formulation containing 5% ORF 13904 was administered to rabbits intravaginally, the mean number of fetal implants was reduced dramatically even when coitus was delayed for up to 8 hours or when multiple matings at different time intervals were permitted. The non-spermicidal qualities and extended duration of action of this compound represent major breakthroughs in the development of vaginal contraceptives. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
