The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans.

Autor: Fedosejevs ET; Department of Biology, Queen's University, Kingston, Canada., Feil R; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany., Lunn JE; Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany., Plaxton WC; Department of Biology, Queen's University, Kingston, Canada.; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2018 Aug; Vol. 592 (15), pp. 2525-2532. Date of Electronic Publication: 2018 Aug 03.
DOI: 10.1002/1873-3468.13197
Abstrakt: In plants, trehalose 6-phosphate (T6P) is a key signaling metabolite that functions as both a signal and negative feedback regulator of sucrose levels. The mode of action by which T6P senses and regulates sucrose is not fully understood. Here, we demonstrate that the sucrolytic activity of RcSUS1, the dominant sucrose synthase isozyme expressed in developing castor beans, is allosterically inhibited by T6P. The feedback inhibition of SUS by T6P may contribute to the control of sink strength and sucrolytic flux in heterotrophic plant tissues.
(© 2018 Federation of European Biochemical Societies.)
Databáze: MEDLINE
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