Ru(II)-Catalyzed Regiospecific C-H/O-H Oxidative Annulation to Access Isochromeno[8,1- ab ]phenazines: Far-Red Fluorescence and Live Cancer Cell Imaging.
| Autor: | Mayakrishnan S; Organic & Bioorganic Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600020, India., Arun Y; Organic & Bioorganic Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600020, India., Balachandran C; Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan., Awale S; Division of Natural Drug Discovery, Department of Translational Research, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan., Maheswari NU; Organic & Bioorganic Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600020, India., Perumal PT; Organic & Bioorganic Chemistry Laboratory, CSIR-Central Leather Research Institute, Chennai 600020, India. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2017 Jun 30; Vol. 2 (6), pp. 2694-2705. Date of Electronic Publication: 2017 Jun 17. |
| DOI: | 10.1021/acsomega.7b00335 |
| Abstrakt: | A facile ruthenium(II)-catalyzed regiospecific C-H/O-H oxidative annulation methodology was developed to construct isochromeno[8,1- ab ]phenazines. This methodology delivers various advantages, such as scope for diverse substrates, tolerance to a range of functional groups, stability under air, and yields regioselective products. This methodology was successfully applied to synthesize far red (FR) fluorescent probes for live cancer cell imaging. The synthesized compounds displayed notable fluorescence properties in solution and thin-film. Their application in live cancer cell imaging was investigated using various cancer cell lines. The synthesized compound showed prominent FR fluorescence, with high quantum yield, and exhibited better cell-imaging properties, with excellent biocompatibility. Competing Interests: The authors declare no competing financial interest. |
| Databáze: | MEDLINE |
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