An efficient formulation based on cationic porphyrins to photoinactivate Staphylococcus aureus and Escherichia coli.

Autor:	Marciel L; Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal., Mesquita MQ; Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal., Ferreira R; Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal., Moreira B; Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal., Pms Neves MG; Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal., F Faustino MA; Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal., Almeida A; Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.
Jazyk:	angličtina
Zdroj:	Future medicinal chemistry [Future Med Chem] 2018 Aug 01; Vol. 10 (15), pp. 1821-1833. Date of Electronic Publication: 2018 Jul 18.
DOI:	10.4155/fmc-2018-0010
Abstrakt:	Aim: Antibiotic resistance is an increasingly serious worldwide problem that needs to be addressed with alternative tools. Antimicrobial photodynamic therapy seems a promising approach but in some cases the synthesis of highly efficient photosensitizers requires laborious processes burdened by extensive chromatographic purifications. In this study, we evaluate the suitability of a formulation (Form-1) containing porphyrins bearing different charges, obtained during the synthesis of the highly efficient photosensitizer 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide. Results: Form-1 was equally effective in the photoinactivation of Escherichia coli and Staphylococcus aureus (reductions >5 log) as the best stand-alone photosensitizer. Conclusion: The effective reduction of bacteria with Form-1 provided promising indications supporting its use, leading to a substantial decrease in costs and production time.
Databáze:	MEDLINE
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