Receptor-binding properties of influenza viruses isolated from gulls.

Autor: Gambaryan AS; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, Russia. Electronic address: al.gambaryan@gmail.com., Matrosovich TY; Institute of Virology, Philipps University, Marburg, Germany., Boravleva EY; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, Russia., Lomakina NF; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, Russia; Gamaleya Scientific Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Yamnikova SS; Gamaleya Scientific Research Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Tuzikov AB; The M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Pazynina GV; The M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Bovin NV; The M.M. Shemyakin-Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia., Fouchier RAM; Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands., Klenk HD; Institute of Virology, Philipps University, Marburg, Germany., Matrosovich MN; Institute of Virology, Philipps University, Marburg, Germany. Electronic address: m.matrosovich@gmail.com.
Jazyk: angličtina
Zdroj: Virology [Virology] 2018 Sep; Vol. 522, pp. 37-45. Date of Electronic Publication: 2018 Jul 12.
DOI: 10.1016/j.virol.2018.07.004
Abstrakt: Ducks, gulls and shorebirds represent the major hosts of influenza A viruses (IAVs) in nature, but distinctions of IAVs in different birds are not well defined. Here we characterized the receptor specificity of gull IAVs with HA subtypes H4, H6, H14, H13 and H16 using synthetic sialylglycopolymers. In contrast to duck IAVs, gull IAVs efficiently bound to fucosylated receptors and often preferred sulfated and non-sulfated receptors with Galβ1-4GlcNAc cores over the counterparts with Galβ1-3GlcNAc cores. Unlike all other IAVs of aquatic birds, H16 IAVs showed efficient binding to Neu5Acα2-6Gal-containing receptors and bound poorly to Neu5Acα2-3Galβ1-3-terminated (duck-type) receptors. Analysis of HA crystal structures and amino acid sequences suggested that the amino acid at position 222 is an important determinant of the receptor specificity of IAVs and that transmission of duck viruses to gulls and shorebirds is commonly accompanied by substitutions at this position.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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