Mycoplasmas and Novel HO-1 Inducers: Recent Advances.

Autor:	Chernov VM; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Kazan, Russian Federation.; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation., Chernova OA; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Kazan, Russian Federation.; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation., Mouzykantov AA; Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, Kazan, Russian Federation.; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation., Lopukhov LV; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation., Trushin MV; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2018; Vol. 24 (20), pp. 2236-2240.
DOI:	10.2174/1381612824666180716170128
Abstrakt:	Inflammation and the Ways for Its Regulation: The development of an effective system for the treatment of inflammatory diseases requires comprehensive studies of the cellular signaling molecular networks comprising responses to various stressors, including pathogenic and non-pathogenic microorganisms. Significant attention on fundamental and applied research has recently focused on inducers of hemе oxygenase-1 (HO-1) and inhibitors of the expression of this enzyme, which regulates expression of this and other cytoprotective molecules and modulation of inflammation. Recent studies indicate that mycoplasmas (a major group of human pathogens of the Mollicutes) are capable of modulating inflammatory responses through the activation of the Nrf2 and the expression of HO-1. In vitro experiments demonstrate that the membrane lipoproteins (LAMPs), along with lipoprotein derivatives (lipopeptide MALP-2) in mycoplasmas cause a "cross-talk" between the pro- and antiinflammatory signaling pathways. Importantly, lipopeptide/lipoprotein - induced expression of HO-1 tends to suppress inflammation. Conclusion: The study of the molecular network that causes the corresponding outcome can facilitate the development of new approaches for the treatment of inflammatory processes. The derivatives of LAMPs and MALP-2 and of their analogues may prove promising for the treatment of diseases associated with chronic inflammation. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu