| Autor: |
Argikar AA; a Department of Pharmacokinetics , KinderPharm LLC , Exton , PA , USA., Argikar UA; b Department of Pharmacokinetic Sciences , Novartis Institutes for BioMedical Research, Inc , Cambridge , MA , USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Drug metabolism reviews [Drug Metab Rev] 2018 Aug; Vol. 50 (3), pp. 398-405. Date of Electronic Publication: 2018 Jul 16. |
| DOI: |
10.1080/03602532.2018.1484756 |
| Abstrakt: |
With the inclusion of mesentery, the total number of human organs has recently increased by one. The mesentery was formerly construed to be a complex, discontinuous anatomical structure simply serving as a support for organs in abdominal cavity. However, recent research has established the mesentery to be a far more simple and unfragmented organ. Newly emerging information on the mesentery has challenged some older pathophysiological concepts. This review briefly discusses the anatomy of the mesentery, historical perspective on the mesentery, embryology, drug metabolizing enzymes and transporters of the mesentery, and the mesentery's role in diseases. The possible impact of the mesentery on absorption, distribution, metabolism, and excretion (ADME) is also discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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