Effect of moderate-intensity statin therapy on plaque inflammation in patients with acute coronary syndrome: A prospective interventional study evaluated by 18F-FDG PET/CT of the carotid artery.

Autor:	Kim CJ; The Catholic Universit of Korea, Uijungbu St. Mary's Hospital, 271, Cheonbo-ro, 11765 Uijeonbu-si, Gyeoggi-do, Korea, Republic Of., Han EJ; Daejeon St. Mary's Hospital, 64, Daeheung-ro, Jung-gu,, 34943 Daejoen, Korea, Republic Of., Chu EH; The Catholic Universit of Korea, Uijungbu St. Mary's Hospital, 271, Cheonbo-ro, 11765 Uijeonbu-si, Gyeoggi-do, Korea, Republic Of., Hwang BH; St.Paul's Hospital, 14, Dapsimni-ro 1-gil, Dongdaemun-gu, 02559 Seoul, Korea, Republic Of., Kim JJ; St.Paul's Hospital, 14, Dapsimni-ro 1-gil, Dongdaemun-gu, 02559 Seoul, Korea, Republic Of., Seung KB; Seoul St. Mary's Hospital, 222, Banpo-daero, Seocho-gu,, 06591 Seoul, Korea, Republic Of., Kim SH; Seoul St. Mary's Hospital, 222, Banpo-daero, Seocho-gu,, 06591 Seoul, Korea, Republic Of., O JH; Seoul St. Mary's Hospital, 222, Banpo-daero, Seocho-gu,, 06591 Seoul, Korea, Republic Of., Chang K; Seoul St. Mary's Hospital, 222, Banpo-daero, Seocho-gu,, 06591 Seoul, Korea, Republic Of. kiyuk@catholic.ac.kr.
Jazyk:	angličtina
Zdroj:	Cardiology journal [Cardiol J] 2020; Vol. 27 (6), pp. 762-771. Date of Electronic Publication: 2018 Jul 16.
DOI:	10.5603/CJ.a2018.0069
Abstrakt:	Background: Asian patients with acute coronary syndrome (ACS) are frequently prescribed moderate- -intensity statin in real practice, even during the early stage of ACS. Under assessment herein was the effect of moderate-intensity statin therapy on the resolution of plaque inflammation during the first month after ACS, a period with highest recurrent ischemic events, using dual time point 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). Methods: This prospective study included statin-naïve patients with ACS and non-calcified carotid plaques (≥ 3 mm on ultrasound images). Baseline FDG PET/CT images of the carotid arteries of the patients were obtained. Then, all patients received atorvastatin (20 mg/day); follow-up FDG PET/CT images of the carotid arteries were then obtained after 1 month of therapy. The primary endpoint measurement was the change in the target-to-background ratio (TBR) of the carotid artery between the initial and follow-up FDG PET/CT scans. Results: Thirteen ACS patients completed the initial and follow-up FDG PET/CT scans. Moderate-intensity statin therapy failed to reduce plaque inflammation at 1 month after ACS (TBR 1.60 ± 0.20 at baseline vs. 1.50 ± 0.40 after therapy; p = 0.422) but significantly reduced serum low-density lipoprotein cholesterol (LDL-C) levels (mean LDL-C 101.2 ± 21.1 mg/dL at baseline vs. 70.7 ± 12.4 mg/dL after therapy; p < 0.001). Changes in the TBR and serum LDL-C levels were not correlated (r = -0.27, p = 0.243). Conclusions: Dual time point FDG PET/CT imaging demonstrates that moderate-intensity statin therapy was insufficient in suppressed plaque inflammation within the first month after ACS in Asian patients, even though achieving target LDL levels.
Databáze:	MEDLINE
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