Influence of Sodium Selenite on the mRNA Expression of the Mammalian Selenocysteine-Containing Protein Genes in Testicle and Prostate Cancer Cells.
| Autor: | Kuznetsova YP; Voronezh State University of Engineering Technology, Voronezh, 394036, Russia., Goltyaev MV; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia. goltayev@mail.ru., Gorbacheva OS; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia., Novoselov SV; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia., Varlamova EG; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia., Fesenko EE; Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2018 May; Vol. 480 (1), pp. 131-134. Date of Electronic Publication: 2018 Jul 14. |
| DOI: | 10.1134/S1607672918030018 |
| Abstrakt: | The sodium selenite concentration that reduces the viability of Du-145 human prostate adenocarcinoma cells and F-9 mouse testicular teratocarcinoma cells was determined. We investigated the effect of sodium selenite on the mRNA expression level of the genes encoding mammalian selenocysteine-containing glutathione peroxidases and thioredoxin reductases (key antioxidant enzymes involved in the regulation of intracellular thiol redox balance), endoplasmic reticulum selenoproteins, and selenoproteins located in the testes and prostate. |
| Databáze: | MEDLINE |
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