Treatment of infantile spasms in Saudi Arabia.
| Autor: | Alqassas MA; Departments of Pediatrics, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia., Muthaffar OY, Aljawi AA, Taj AM, Nijaifan HK, Alyoubi RA, Jan MM |
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| Jazyk: | angličtina |
| Zdroj: | Neurosciences (Riyadh, Saudi Arabia) [Neurosciences (Riyadh)] 2018 Jul; Vol. 23 (3), pp. 258-261. |
| DOI: | 10.17712/nsj.2018.3.20180015 |
| Abstrakt: | Objective: To evaluate the treatment approach and compliance of pediatric neurologists with evidence-based guidelines across Kingdom of Saudi Arabia (KSA). These guidelines that clarify the optimal management of infantile spasms (IS) are not widely followed for various practical reasons. Methods: Physicians practicing in the field of pediatric neurology in KSA were contacted from the database of national societies. A cross-sectional study was conducted using a structured 20-item on-line survey designed to examine their clinical experience with IS and their treatment choices. Results: A total of 52 pediatric neurologists completed the survey (69% estimated capture rate). They received their formal training within KSA (40%), North America (33%), or Europe (14%). The majority practiced in 2 major cities, Riyadh (46%) or Jeddah (19%). Vigabatrin was favored over adrenocorticotropic hormone (ACTH) as first line drug for patients without tuberous sclerosis complex (48% vs. 21%). Several factors correlated with correctly selecting ACTH as first line including western training (33% vs. 5%, p=0.001), practicing in the city of Riyadh (25% vs. 14%, p=0.001), or having >10 years of clinical experience (25% vs. 5%, p=0.017). Reasons for not complying with the recommended treatment guidelines included lack of availability of ACTH (42%), side effect profile of steroids (29%), and personal preferences (14%). Only 4% admitted lack of awareness of the currently published management guidelines. Conclusion: Many pediatric neurologists in KSA are not following the published IS management guidelines. Using ACTH as first line correlated with their training, practice location, and years of experience. Lack of drug availability and side effect profile were common reasons for not complying with the management guidelines. |
| Databáze: | MEDLINE |
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