Zein-polysaccharide nanoparticles as matrices for antioxidant compounds: A strategy for prevention of chronic degenerative diseases.

Autor: Tapia-Hernández JA; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico., Rodríguez-Felix F; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: francisco.rodriguezfelix@unison.mx., Juárez-Onofre JE; Department of Physics, University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: josue.juarez@unison.mx., Ruiz-Cruz S; Department of Biotechnology and Food Science. Institute Technology of Sonora. 5 de febrero #818 sur, Colonia Centro, 85000 Ciudad Obregón, Sonora, Mexico. Electronic address: saul.ruiz@itson.edu.mx., Robles-García MA; Department of Medical Scinces and Life, University of Guadalajara, 1115. Ocotlán, Jalisco, Mexico., Borboa-Flores J; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: jesus.borboa@unison.mx., Wong-Corral FJ; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: francisco.wong@unison.mx., Cinco-Moroyoqui FJ; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: javier.cinco@unison.mx., Castro-Enríquez DD; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico., Del-Toro-Sánchez CL; Department of Research and Posgraduate in Food (DIPA). University of Sonora, Blvd. Luis Encinas y Rosales, S/N, Colonia Centro, 83000 Hermosillo, Sonora, Mexico. Electronic address: carmen.deltoro@unison.mx.
Jazyk: angličtina
Zdroj: Food research international (Ottawa, Ont.) [Food Res Int] 2018 Sep; Vol. 111, pp. 451-471. Date of Electronic Publication: 2018 May 25.
DOI: 10.1016/j.foodres.2018.05.036
Abstrakt: Oxidative Stress (OS) produces the formation of free radicals and other reactive oxygen and nitrogen species that are intimately involved in many diseases, especially Chronic Degenerative Diseases (CDD) such as cancer, diabetes, cardiovascular diseases, and obesity, among others. Thus, reactive compounds need to be quenched by antioxidants. The problems of these compounds include that they are susceptible to degradation, have low bioavailability, and can lose their bioactivity in the gastroIntestinal tract. Therefore, an alternative is encapsulation. Zein is a protein used in nanotechnology as a polymer matrix because it can encapsulate different compounds such as antioxidants to provide stability and control of the release. The disadvantage of zein as a delivery vehicle is that it is limited by the low stability of aggregation when suspended in water, in addition to the conditions of acid pH or that higher ionic strength tends to destabilize. To reduce these limitations, the incorporation of polysaccharides as a second polymer matrix can provide stability in zein nanoparticles. In this review, we discuss OS as a source of CDD, the role of antioxidants in the prevention of these diseases, and the preparation, characterization, and application of antioxidant-zein-polysaccharide particles as delivery systems as well as possible mechanisms to control CDD.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: