Intrinsic connectivity network dynamics in PTSD during amygdala downregulation using real-time fMRI neurofeedback: A preliminary analysis.

Autor:	Nicholson AA; Department of Neuroscience, Western University, London, Ontario, Canada.; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada.; Homewood Research Institute, Guelph, Ontario, Canada., Rabellino D; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada.; Homewood Research Institute, Guelph, Ontario, Canada., Densmore M; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada., Frewen PA; Department of Neuroscience, Western University, London, Ontario, Canada.; Department of Psychology, Western University, London, Ontario, Canada., Paret C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Kluetsch R; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Schmahl C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany., Théberge J; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada.; Department of Medical Imaging, Western University, London, Ontario, Canada.; Department of Medial Biophysics, Western University, London, Ontario, Canada.; Department of Diagnostic Imaging, St. Joseph's Healthcare, London, Ontario, Canada., Ros T; Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience, University of Geneva, Geneva, Switzerland., Neufeld RWJ; Department of Neuroscience, Western University, London, Ontario, Canada.; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Psychology, Western University, London, Ontario, Canada., McKinnon MC; Homewood Research Institute, Guelph, Ontario, Canada.; Mood Disorders Program, St. Joseph's Healthcare, Hamilton, Ontario, Canada.; Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada., Reiss JP; Department of Psychiatry, Western University, London, Ontario, Canada., Jetly R; Canadian Forces, Health Services, Ottawa, Ontario, Canada., Lanius RA; Department of Neuroscience, Western University, London, Ontario, Canada.; Department of Psychiatry, Western University, London, Ontario, Canada.; Department of Imaging, Lawson Health Research Institute, London, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2018 Nov; Vol. 39 (11), pp. 4258-4275. Date of Electronic Publication: 2018 Jul 13.
DOI:	10.1002/hbm.24244
Abstrakt:	Posttraumatic stress disorder (PTSD) has been associated with a disturbance in neural intrinsic connectivity networks (ICN), including the central executive network (CEN), default mode network (DMN), and salience network (SN). Here, we conducted a preliminary investigation examining potential changes in ICN recruitment as a function of real-time fMRI neurofeedback (rt-fMRI-NFB) during symptom provocation where we targeted the downregulation of neural response within the amygdala-a key region-of-interest in PTSD neuropathophysiology. Patients with PTSD (n = 14) completed three sessions of rt-fMRI-NFB with the following conditions: (a) regulate: decrease activation in the amygdala while processing personalized trauma words; (b) view: process trauma words while not attempting to regulate the amygdala; and (c) neutral: process neutral words. We found that recruitment of the left CEN increased over neurofeedback runs during the regulate condition, a finding supported by increased dlPFC activation during the regulate as compared to the view condition. In contrast, DMN task-negative recruitment was stable during neurofeedback runs, albeit was the highest during view conditions and increased (normalized) during rest periods. Critically, SN recruitment was high for both the regulate and the view conditions, a finding potentially indicative of CEN modality switching, adaptive learning, and increasing threat/defense processing in PTSD. In conclusion, this study provides provocative, preliminary evidence that downregulation of the amygdala using rt-fMRI-NFB in PTSD is associated with dynamic changes in ICN, an effect similar to those observed using EEG modalities of neurofeedback. (© 2018 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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