Telocytes role during the postnatal development of the Mongolian gerbil jejunum.

Autor: Zani BC; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil., Sanches BDA; Department of Structural and Functional Biology, State University of Campinas, Bertrand Russel Av., Campinas, São Paulo, Brazil., Maldarine JS; Department of Structural and Functional Biology, State University of Campinas, Bertrand Russel Av., Campinas, São Paulo, Brazil., Biancardi MF; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Santos FCA; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Barquilha CN; Univ. Estadual Paulista - UNESP, Institute of Biosciences, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District, Botucatu, São Paulo 18618-689, Brazil., Zucão MI; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil., Baraldi CMB; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil., Felisbino SL; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil; Univ. Estadual Paulista - UNESP, Institute of Biosciences, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District, Botucatu, São Paulo 18618-689, Brazil., Góes RM; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil; Department of Structural and Functional Biology, State University of Campinas, Bertrand Russel Av., Campinas, São Paulo, Brazil., Vilamaior PSL; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil., Taboga SR; Univ. Estadual Paulista - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Cristóvão Colombo St., 2265, São José do Rio Preto, São Paulo, Brazil; Department of Structural and Functional Biology, State University of Campinas, Bertrand Russel Av., Campinas, São Paulo, Brazil. Electronic address: taboga@ibilce.unesp.br.
Jazyk: angličtina
Zdroj: Experimental and molecular pathology [Exp Mol Pathol] 2018 Aug; Vol. 105 (1), pp. 130-138. Date of Electronic Publication: 2018 Jul 09.
DOI: 10.1016/j.yexmp.2018.07.003
Abstrakt: Telocytes are recently categorised CD34-positive interstitial cells that comprise the cells which were previously called interstitial Cajal-like cells (ICLCs). These were detected in the stroma of various organs such as the prostate, lungs, mammary glands, liver, gallbladder, and jejunum, among others. Several functions have been proposed for telocytes, such as a supportive role in smooth muscle contraction and immune function in adult organs, and tissue organisation and paracrine signalling during development, as well as others. In the jejunum, little is known about the function of telocytes in the adult organ, or is there any information about when these cells develop or if they could have an auxiliary role in the development of the jejunum. The present study employed histological, immunohistochemical and immunofluorescence techniques on histological sections of the jejunum of Mongolian gerbil pups on two different days of postnatal development of the jejunum, covering the maturation period of the organ. By immunolabelling for CD34, it was observed that telocytes are already present in the jejunum during the first week of postnatal life and exist in close association with the developing muscularis mucosae, which are therefore TGFβ1-positive. The telocytes are still present at the end of the first month of life, and a portion of them present co-localisation with c-Kit. Fibroblast-like cells, which are exclusively c-Kit-positive, are also observed, which may indicate the presence of interstitial Cajal cells (ICCs). Finally, it can be hypothesised that a portion of the telocytes may give rise to ICCs, which are c-Kit-positive but CD34 negative.
(Copyright © 2018. Published by Elsevier Inc.)
Databáze: MEDLINE
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