CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS AND SURVIVAL OUTCOMES OF CHILDREN WITH NEUROBLASTOMA: 21 YEARS OF EXPERIENCE AT THE INSTITUTO DE ONCOLOGIA PEDIÁTRICA, IN SÃO PAULO, BRAZIL.
Autor: | Lucena JN; Universidade Federal de São Paulo, São Paulo, SP, Brasil., Alves MTS; Universidade Federal de São Paulo, São Paulo, SP, Brasil., Abib SCV; Universidade Federal de São Paulo, São Paulo, SP, Brasil., Souza GO; Universidade Federal de São Paulo, São Paulo, SP, Brasil., Neves RPC; Universidade Federal de São Paulo, São Paulo, SP, Brasil., Caran EMM; Universidade Federal de São Paulo, São Paulo, SP, Brasil. |
---|---|
Jazyk: | Portuguese; English |
Zdroj: | Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo [Rev Paul Pediatr] 2018 Jul-Sep; Vol. 36 (3), pp. 254-260. Date of Electronic Publication: 2018 Jul 10. |
DOI: | 10.1590/1984-0462/;2018;36;3;00007 |
Abstrakt: | Objective: To describe the clinical and epidemiological characteristics and survival outcomes of children with neuroblastoma (NB) treated at a pediatric oncology center from 1991 to 2012. Methods: A retrospective study with clinical and epidemiological data from 258 patients with neuroblastoma treated at a pediatric oncology center from 1991 to 2012, using medical records. Results: The average age of the children at diagnosis was 40.5±46.4 months with a median age of 28.9 months (interquartile range 42.2). The male:female ratio was 1.3:1, and 1% of the patients were asymptomatic. The most frequent manifestations were: fever (25%), abdominal pain (22%), abdominal mass (19%), and bone pain (19%). The mean time from symptom onset to diagnosis was 3.0±4.8 months. The most common location of the tumor was the abdomen (63%). Metastases occurred in the bone marrow (37%) and in the bone (33%). Overall survival (OS) and event-free survival (EFS) in five years were 62 and 52%, respectively. The main cause of death was the progression of the disease (72%). Conclusions: The clinical features of children with neuroblastoma are variable and mostly nonspecific, which makes clinical recognition difficult and, in general, too late. In children less than 5 years old, with an abdominal mass and/or bone pain, irritability, and a fever from an unknown cause, neuroblastoma should be considered as a possible diagnosis. |
Databáze: | MEDLINE |
Externí odkaz: |