Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta.

Autor: Leviton A; Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Allred EN; Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Joseph RM; Boston University School of Medicine, Boston, MA, USA., O'Shea TM; University of North Carolina School of Medicine, Chapel Hill, NC, USA., Majzoub J; Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Kuban KCK; Boston University School of Medicine, Boston, MA, USA.; Boston Medical Center, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2018 Nov; Vol. 107 (11), pp. 1932-1936. Date of Electronic Publication: 2018 Aug 07.
DOI: 10.1111/apa.14494
Abstrakt: Aim: To evaluate the relationship between corticotropin-releasing hormone (CRH) expression in the placenta and the risk of school-related dysfunctions at the age of 10 years among children born extremely preterm (EP).
Methods: Corticotropin-releasing hormone expression was measured in the placenta of 761 EP children, who had the following assessments at the age of 10 years: Differential Ability Scales, Oral and Written Language Scales, the Wechsler Individual Achievement Test-III, NEPSY-II and the Child Symptom Inventory-4. We evaluated whether lowest and highest quartiles of CRH mRNA were associated with undesirable scores on these assessments. With 272 evaluations, we would expect 14 to be significant at p < 0.05.
Results: Only 16 associations were statistically significant. On the other hand, seven of these were social limitations among girls whose placenta CRH mRNA was in the top quartile. Adjusting for delivery indication or restricting the sample to one delivery indication group resulted in few differences.
Conclusion: Overall, placenta CRH mRNA concentrations in the top or bottom quartiles were not associated with increased risks of dysfunctions 10 years later. Girls whose placenta CRH expression was in the top quartile, however, were at increased risk of seven indicators/correlates of social limitations.
(©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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