Behçet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study.

Autor:	Uluduz D; School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul., Midi I; School of Medicine, Department of Neurology, Marmara University, Istanbul., Duman T; School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay., Colakoglu S; School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay., Tüfekci A; School of Medicine, Department of Neurology, Recep Tayyip Erdoğan University, Rize., Bakar M; School of Medicine, Department of Neurology, Uludağ University, Bursa., Nazliel B; School of Medicine, Department of Neurology, Gazi University, Ankara., Tascilar N; School of Medicine, Department of Neurology, Bülent Ecevit University, Zonguldak., Goksan B; School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul., Sungur MA; School of Medicine, Department of Biostatistics, Düzce University, Düzce., Kozak HH; School of Medicine, Department of Neurology, Necmettin Erbakan University, Konya., Demir S; Clinic of Neurology, Sultan Abdulhamid Han Research and Training Hospital, Istanbul., Misirli CH; Clinic of Neurology, Haydarpasa Training and Research Hospital, Health Sciences University, Istanbul., Kucukoglu H; Clinic of Neurology, Bakirkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Istanbul., Cinar N; School of Medicine, Department of Neurology, Maltepe University, Istanbul., Domac FM; Clinic of Neurology, Erenkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Istanbul., Ozturk S; School of Medicine, Department of Neurology, Selçuk University, Konya., Yayla V; Clinic of Neurology, Bakirkoy Sadi Konuk Research and Training Hospital, Istanbul., Karahan AY; School of Medicine, Department of Physical Medicine and Rehabilitation, Usak University, Usak., Afsar N; School of Medicine, Department of Neurology, Acibadem Mehmet Ali Aydinlar University, Istanbul., Goksu EO; Clinic of Neurology, Antalya Research and Training Hospital, Antalya., Mengulluoglu N; Clinic of Neurology, Eskisehir Government Hospital, Eskisehir., Aytac E; Clinic of Neurology, Ankara Research and Training Hospital, Ankara., Yesilot N; Department of Neurology, Istanbul University, Istanbul Faculty of Medicine Istanbul., Ince B; School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul., Yalin OO; Clinic of Neurology, Istanbul Training and Research Hospital, Health Sciences University, Istanbul., Oruc S; School of Medicine, Department of Neurology, Kocatepe University, Afyon., Demirci S; School of Medicine, Department of Neurology, Süleyman Demirel University, Isparta., Senol MG; School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul., Yilmaz A; School of Medicine, Department of Neurology, Mersin University, Mersin., Gokce M; School of Medicine, Department of Neurology, Kahramanmaras Sutcu Imam University, Kahramanmaras., Yilmaz Kusbeci Ö; Clinic of Neurology, Bozyaka Education, Research and Training Hospital, İzmir., Uzuner G; School of Medicine, Department of Neurology, Osmangazi University, Eskisehir., Batur Caglayan HZ; School of Medicine, Department of Neurology, Gazi University, Ankara., Acikgoz M; School of Medicine, Department of Neurology, Bülent Ecevit University, Zonguldak., Zeydan B; School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul., Ozdag F; Clinic of Neurology, Sultan Abdulhamid Han Research and Training Hospital, Istanbul., Baybas S; Clinic of Neurology, Bakirkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Istanbul., Ekmekci H; School of Medicine, Department of Neurology, Selçuk University, Konya., Cabalar M; Clinic of Neurology, Bakirkoy Sadi Konuk Research and Training Hospital, Istanbul., Yaman M; School of Medicine, Department of Neurology, Kocatepe University, Afyon., Yurekli VA; School of Medicine, Department of Neurology, Süleyman Demirel University, Isparta., Tekeli H; Clinic of Neurology, Sultan Abdulhamid Han Research and Training Hospital, Istanbul., Genc H; School of Medicine, Department of Neurology, Mersin University, Mersin., Utku U; School of Medicine, Department of Neurology, Kahramanmaras Sutcu Imam University, Kahramanmaras., Ucan Tokuc FE; Clinic of Neurology, Antalya Research and Training Hospital, Antalya., Uzuner N; School of Medicine, Department of Neurology, Osmangazi University, Eskisehir., Bektas H; Clinic of Neurology, Ataturk Research and Training Hospital, Ankara., Kablan Y; School of Medicine, Department of Neurology, Inonu University, Malatya., Goksel BK; School of Medicine, Department of Neurology, Baskent University, Adana., Milanlioglu A; School of Medicine, Department of Neurology, Yüzüncü Yıl University, Van, Turkey., Necioglu Orken D; Department of Neurology, Istanbul Bilim University, Istanbul, Turkey., Aluclu U; School of Medicine, Department of Neurology, Dicle University, Diyarbakir, Turkey.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2019 Apr 01; Vol. 58 (4), pp. 600-608.
DOI:	10.1093/rheumatology/key153
Abstrakt:	Objective: This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behçet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods: VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results: BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions: BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score ⩾2). (© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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