Diabetes Mellitus and Autoimmune Hepatitis: Demographical and Clinical Description of a Relatively Rare Phenotype.

Autor:	de Sousa G; Children's Hospital Dortmund, Dortmund, Germany.; Department of Pediatrics, University of Witten/Herdecke, Witten, Germany., Prinz N; Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Munich, Germany., Becker M; Children's Hospital, Helios Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Dürr R; Children's Hospital Rems-Murr, Winnenden, Germany., Faller U; Children's Hospital, Oberschwabenklinik, Ravensburg, Germany., Meraner D; Department of Pediatrics and Adolescent Medicine, University Innsbruck, Innsbruck, Austria., Heise N; Department of Internal Medicine, Helfenstein Klinik, Geislingen/Steige, Germany., Engelmann I; Department of Internal Medicine, Medius Kliniken, Nürtingen, Germany., Bruckmayer H; Department of Internal Medicine, Hospital Ruhpolding, Ruhpolding, Germany., Wiemann D; Department of Pediatrics, University of Magdeburg, Magdeburg, Germany., Fritsch M; Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria., Stratmann B; Diabeteszentrum, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany., Holl RW; Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2018 Jul; Vol. 50 (7), pp. 568-574. Date of Electronic Publication: 2018 Jul 10.
DOI:	10.1055/a-0631-2468
Abstrakt:	We studied demographic, metabolic, and clinical characteristics of patients with diabetes and autoimmune hepatitis (AIH) from the German/Austrian DPV registry. A total of 139 patients with diabetes and AIH were analyzed and compared to 437 728 patients with diabetes without AIH. The prevalence of AIH in patients with T1DM (44.8/100 000) seems higher than in the general population, the prevalence of AIH in patients with T2DM (23.6/100 000) does not seem to be increased. Patients with T2DM and AIH had a shorter duration of diabetes (p=0.007) and a higher proportion of females (p<0.001) compared to T2DM without AIH. Patients with diabetes (T1DM or T2DM) and AIH required higher insulin doses (p<0.001 and p=0.03, respectively) and showed increased liver enzymes (aspartate transaminase, alanine transaminase, gamma-glutamyltransferase) compared to diabetes patients without (all p<0.001). We detected a lower percentage of patients treated with oral antidiabetic drugs (p=0.01) and a higher percentage of patients treated by insulin in patients with T2DM and AIH (p<0.001) compared to patients with T2DM alone. We observed a higher incidence of autoimmune thyroid disease (AIT) in patients with diabetes (T1DM or T2DM) and AIH (p<0.001) compared to diabetes patients without AIH. AIH seems more frequent in patients with T1DM. Patients with diabetes and AIH require intensification of antidiabetic therapy and seem to have a higher prevalence of AIT. Competing Interests: The authors declare that they have no conflict of interest. (© Georg Thieme Verlag KG Stuttgart · New York.)
Databáze:	MEDLINE
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