Applications of stem cells in orthodontics and dentofacial orthopedics: Current trends and future perspectives.
| Autor: | Safari S; Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 13819, Iran., Mahdian A; Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 13819, Iran., Motamedian SR; Department of Orthodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 13819, Iran. sr.motamedian@yahoo.com. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of stem cells [World J Stem Cells] 2018 Jun 26; Vol. 10 (6), pp. 66-77. |
| DOI: | 10.4252/wjsc.v10.i6.66 |
| Abstrakt: | A simple overview of daily orthodontic practice involves use of brackets, wires and elastomeric modules. However, investigating the underlying effect of orthodontic forces shows various molecular and cellular changes. Also, orthodontics is in close relation with dentofacial orthopedics which involves bone regeneration. In this review current and future applications of stem cells (SCs) in orthodontics and dentofacial orthopedics have been discussed. For craniofacial anomalies, SCs have been applied to regenerate hard tissue (such as treatment of alveolar cleft) and soft tissue (such as treatment of hemifacial macrosomia). Several attempts have been done to reconstruct impaired temporomandibular joint. Also, SCs with or without bone scaffolds and growth factors have been used to regenerate bone following distraction osteogenesis of mandibular bone or maxillary expansion. Current evidence shows that SCs also have potential to be used to regenerate infrabony alveolar defects and move the teeth into regenerated areas. Future application of SCs in orthodontics could involve accelerating tooth movement, regenerating resorbed roots and expanding tooth movement limitations. However, evidence supporting these roles is weak and further studies are required to evaluate the possibility of these ideas. Competing Interests: Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported. |
| Databáze: | MEDLINE |
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