Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats.

Autor: Elchaninov AV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia.; Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198, Moscow, Russia., Fatkhudinov TK; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia. fatkhudinov@gmail.com.; Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198, Moscow, Russia. fatkhudinov@gmail.com., Usman NY; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia., Kananykhina EY; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia., Arutyunyan IV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia.; Scientific Research Institute of Human Morphology, 3 Tsurupa Street, 117418, Moscow, Russia., Makarov AV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia.; Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997, Moscow, Russia., Lokhonina AV; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia., Eremina IZ; Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198, Moscow, Russia., Surovtsev VV; Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198, Moscow, Russia., Goldshtein DV; Research Center of Medical Genetics, 1 Moscvorechie, 115478, Moscow, Russia., Bolshakova GB; Scientific Research Institute of Human Morphology, 3 Tsurupa Street, 117418, Moscow, Russia., Glinkina VV; Ministry of Healthcare of the Russian Federation, Pirogov Russian National Research Medical University, 1 Ostrovitianov Street, 117997, Moscow, Russia., Sukhikh GT; National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, 117997, Moscow, Russia.
Jazyk: angličtina
Zdroj: BMC immunology [BMC Immunol] 2018 Jul 09; Vol. 19 (1), pp. 23. Date of Electronic Publication: 2018 Jul 09.
DOI: 10.1186/s12865-018-0260-1
Abstrakt: Background: In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats.
Results: The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnfα, the observed growth inhibition may be related to particular properties of liver macrophages - the resident Kupffer cells with CD68 + CX1CR3 - CD11b - phenotype.
Conclusions: The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration.
Databáze: MEDLINE
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