Physiological costs of infection: herpesvirus replication is linked to blood oxidative stress in equids.

Autor:	Costantini D; UMR 7221 CNRS/MNHN, Muséum National d'Histoire Naturelle, Sorbonne Universités, 7 rue Cuvier, 75005, Paris, France. david.costantini@mnhn.fr.; Institute for Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, G12 8QQ, Glasgow, Scotland, UK. david.costantini@mnhn.fr.; Department of Biology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. david.costantini@mnhn.fr., Seeber PA; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., Soilemetzidou SE; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., Azab W; Institut für Virologie, Robert von Ostertag-Haus, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163, Berlin, Germany., Bohner J; Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., Buuveibaatar B; Wildlife Conservation Society, Mongolia Program, Ulaanbaatar, Mongolia., Czirják GÁ; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., East ML; Department of Ecological Dynamics, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., Greunz EM; Center for Zoo and Wild Animal Health, Copenhagen Zoo, Roskildevej 38, 2000, Frederiksberg, Denmark.; Parc Zoologique de Thoiry, Rue du Pavillon de Montreuil, 78770, Thoiry, France., Kaczensky P; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, A-1160, Vienna, Austria.; Norwegian Institute for Nature Research - NINA, Sluppen, NO-7485, Trondheim, Norway., Lamglait B; Faculty of Veterinary Medicine, Université de Montréal, 3200 Rue Sicotte, Saint-Hyacinthe, Québec, J2S 2N4, Canada.; Réserve Africaine de Sigean, 19 Chemin Hameau du Lac, RD 6009, 11130, Sigean, France., Melzheimer J; Department of Evolutionary Ecology, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany., Uiseb K; Ministry of Environment and Tourism, Private Bag 13301, Windhoek, Namibia., Ortega A; Réserve Africaine de Sigean, 19 Chemin Hameau du Lac, RD 6009, 11130, Sigean, France., Osterrieder N; Institut für Virologie, Robert von Ostertag-Haus, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163, Berlin, Germany., Sandgreen DM; Givskud Zoo, Løveparkvej 3, Givskud, 7323, Give, Denmark., Simon M; Parc Zoologique de Thoiry, Rue du Pavillon de Montreuil, 78770, Thoiry, France., Walzer C; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, A-1160, Vienna, Austria.; Wildlife Conservation Society, 2300 Southern Blvd., 10460, Bronx, New York, USA., Greenwood AD; Department of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Straße 17, 10315, Berlin, Germany.; Department of Veterinary Medicine, Freie Universität Berlin, Oertzenweg 19, Berlin, 14163, Germany.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2018 Jul 09; Vol. 8 (1), pp. 10347. Date of Electronic Publication: 2018 Jul 09.
DOI:	10.1038/s41598-018-28688-0
Abstrakt:	Viruses may have a dramatic impact on the health of their animal hosts. The patho-physiological mechanisms underlying viral infections in animals are, however, not well understood. It is increasingly recognized that oxidative stress may be a major physiological cost of viral infections. Here we compare three blood-based markers of oxidative status in herpes positive and negative individuals of the domestic horse (Equus ferus caballus) and of both captive and free-ranging Mongolian khulan (Equus hemionus hemionus) and plains zebra (Equus quagga). Herpes positive free-ranging animals had significantly more protein oxidative damage and lower glutathione peroxidase (antioxidant enzyme) than negative ones, providing correlative support for a link between oxidative stress and herpesvirus infection in free-living equids. Conversely, we found weak evidence for oxidative stress in herpes positive captive animals. Hence our work indicates that environment (captive versus free living) might affect the physiological response of equids to herpesvirus infection. The Mongolian khulan and the plains zebra are currently classified as near threatened by the International Union for Conservation of Nature. Thus, understanding health impacts of pathogens on these species is critical to maintaining viable captive and wild populations.
Databáze:	MEDLINE
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