Optical properties and antiangiogenic activity of a chalcone derivate.

Autor: Lemes SR; Doutorado em Biotecnologia e Biodiversidade, Universidade Federal de Goiás, Campus-II, 74690-900 Goiânia, Goiás, Brazil. Electronic address: susynzr@gmail.com., Júnior LA; Instituto de Física, Universidade Federal de Goiás, Campus-II, 74001-970 Goiânia, Goiás, Brazil., da Silva Manoel D; Instituto de Física de São Carlos, Universidade de São Paulo, 13560-970 São Carlos, SP, Brazil., de Sousa MAM; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás, 74605-010 Goiânia, Goiás, Brazil., Fonseca RD; Instituto de Física de São Carlos, Universidade de São Paulo, 13560-970 São Carlos, SP, Brazil; Departamento de Ciencias Básicas, Universidad de la Costa, 58 No 55-66, 080002 Barranquilla, Atlantico, Colombia., Lima RS; Instituto de Química, Universidade Federal de Goiás, Campus-II, 74001970 Goiânia, Goiás, Brazil., Noda-Perez C; Instituto de Química, Universidade Federal de Goiás, Campus-II, 74001970 Goiânia, Goiás, Brazil., de Melo Reis PR; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás, 74605-010 Goiânia, Goiás, Brazil., Cardoso CG; Departamento de Histologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus-II, 74690-900 Goiânia, Goiás, Brazil., de Paula Silveira-Lacerda E; Laboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus-II, 74001-970 Goiânia, Goiás, Brazil., Souza MAR; Instituto de Física, Universidade Federal de Goiás, Campus-II, 74001-970 Goiânia, Goiás, Brazil., Mendonça CR; Instituto de Física de São Carlos, Universidade de São Paulo, 13560-970 São Carlos, SP, Brazil., Gonçalves PJ; Instituto de Física, Universidade Federal de Goiás, Campus-II, 74001-970 Goiânia, Goiás, Brazil; Instituto de Química, Universidade Federal de Goiás, Campus-II, 74001970 Goiânia, Goiás, Brazil., de Boni L; Instituto de Física de São Carlos, Universidade de São Paulo, 13560-970 São Carlos, SP, Brazil., da Fonseca TL; Instituto de Física, Universidade Federal de Goiás, Campus-II, 74001-970 Goiânia, Goiás, Brazil., da Silva Junior NJ; Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás, 74605-010 Goiânia, Goiás, Brazil.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2018 Nov 05; Vol. 204, pp. 685-695. Date of Electronic Publication: 2018 Jun 28.
DOI: 10.1016/j.saa.2018.06.099
Abstrakt: Chalcones and their derivatives exhibit numerous pharmacological activities such as antibacterial, antifungal, cytotoxic, antinociceptive and anti-inflammatory. Recently, they have been assessed aiming for novel application in nonlinear optics and in the treatment of immune diseases and cancers. In this study, we investigate the optical properties of synthetic chalcona 1E,4E-1-(4-chlorophenyl)-5-(2,6,6-trimethylcyclohexen-1-yl)penta-1,4-dien-3-one (CAB7β) and its antiangiogenic potential using the chorioallantoic membrane (CAM) with the S180 sarcoma cell line. Experimental and theoretical results show intense absorption in the UVA-UVC region, which is associated with a π → π* transition with intramolecular charge transfer from the trimethyl-cyclohexen-1-yl ring to the chlorophenyl ring. Quantum chemical calculations of the first hyperpolarizability, accounting for both solvent and frequency dispersion effects, are in very good concordance with hyper-Rayleigh scattering measurements. In addition, two-photon absorption allowed band centered at 650 nm was observed. Concerning antiangiogenic activity, CAB7β causes a significant reduction in the total number, junctions, length and caliber of blood vessels stimulated by S180 cells reducing the presence of blood vessels, inflammatory cells and others elements related to angiogenic process. It is found that CAB7β is a versatile compound and a promising candidate for linear and nonlinear optical applications, in therapy against sarcoma and phototherapy.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: